CAJ | 학술논문

目的了解输血后丙型肝炎病毒感染者的临床特征及其自然病史.方法采用横断面调查与回顾性调查相结合的方法,对1998年1月-2002年7月输受同一供血者血液的83侈HCV感染患者进行临床资料调查,同时进行抗-HCV,HCV RNA,肝功能生物化学指标,腹部B型超声检查.计量资料用7检验,计数资料用x2检验,等级资料用秩和检验.结果抗-HCV阳性83例,HCV RNA阳性56例,丙型肝炎慢性化率为67.4%,其中男性76.3%(29/38),女性60.00%(27/45),两者差异无统计学意义(x2=2.99,P=0.11).HCV RNA阳性组的平均年龄为(36.54±14.37)岁,HCV RNA阴性组平均年龄为(27.43±12.51)岁,差异有统计学意义(T=-2.41,P=0.018).供血者感染HCV基因为1b型.HCV RNA阳性患者中有10例表现为轻度乏力、纳差、腹胀,9例ALT轻度升高,12例B型超声检查提示有慢性肝炎改变,1例为肝硬化失代偿期.结论输血后感染HCV者临床表现隐匿,慢性化与受感染时的年龄有一定关系.
목적 료해수혈후병형간염병독감염자적림상특정급기자연병사.방법 채용횡단면조사여회고성조사상결합적방법,대1998년1월-2002년7월수수동일공혈자혈액적83치HCV감염환자진행림상자료조사,동시진행항-HCV,HCV RNA,간공능생물화학지표,복부B형초성검사.계량자료용7검험,계수자료용x2검험,등급자료용질화검험.결과 항-HCV양성83례,HCV RNA양성56례,병형간염만성화솔위67.4%,기중남성76.3%(29/38),녀성60.00%(27/45),량자차이무통계학의의(x2=2.99,P=0.11).HCV RNA양성조적평균년령위(36.54±14.37)세,HCV RNA음성조평균년령위(27.43±12.51)세,차이유통계학의의(T=-2.41,P=0.018).공혈자감염HCV기인위1b형.HCV RNA양성환자중유10례표현위경도핍력、납차、복창,9례ALT경도승고,12례B형초성검사제시유만성간염개변,1례위간경화실대상기.결론 수혈후감염HCV자림상표현은닉,만성화여수감염시적년령유일정관계.
Objective To find out clinical characteristics and natural history of post transfusion HCV infection. Methods 83 subjects who have received the blood from a same blood donor from January 1998 to July 2002 were investigated by the method combining cross-sectional study with retrospective study. HC V-antibody, HCV RNA, liver function, abdomen B-ultrasound and Fibroscan were detected. Results The HCV-antibody were all positive. The HCV RNA of 56 out of the 83 cases were positive. The chronicity rates of hepatis C were 76.3% (29/38) in male patients and 60.00% (27/45) in female patients respectively, without significant difference (x2 = 2.99, P = 0.11). The average age of the HCV RNA positive patients was (36.54 ± 14.37) years old. The average age of the HCV RNA negative patients was (27.43 ± 12.51) years old. A significant difference (T = -2.41, P = 0.018) existed between. The HCV genotype was typelb. Among the HCV RNA positive patients, 10 cases were with mild asthenia, anorexia and abdominal distention, 9 cases with increased serum ALT, 12 cases.with chronic hepatitis and 1 case was diagnosed with decompensated liver cirrhosis. Conclusion The clinical manifestations of HCV infection are occult and chronic. The chronicity rate is related to gender and the age when infection was caught.