CAJ | 학술논문

目的评估低蛋白饮食对3/4期慢性肾脏病(CKD)患者肾功能水平及营养状况的影响.方法将34例3/4期CKD患者随机分为A组(n=14)和B组(n=20),分别给予0.6 g·kg~(-1)·d~(-1) 和0.8 g·kg~(-1)·d~(-1)蛋白质摄入量,对两组患者个体化跟踪指导6个月,测定治疗前后人体测量指标及血生化指标,进行人体营养状况整体评价和24 h膳食回顾调查.结果 A组治疗后血肌酐值水平明显下降(P=0.010),白蛋白水平明显升高(P=0.042),热能(P=0.018)和碳水化合物(P<0.001)的摄入均较治疗前明显提高.通过营养干预,整体、A组和B组患者营养不良发生率比治疗前分别下降了14.7%、7.2%和21.1%.结论 0.6 g·kg~(-1)·d~(-1)蛋白质摄入量及用小麦淀粉代替部分主食的饮食方案可明显提高3/4期CKD患者碳水化合物和热能的摄入量,改善其营养状况和肾功能.
목적 평고저단백음식대3/4기만성신장병(CKD)환자신공능수평급영양상황적영향.방법 장34례3/4기CKD환자수궤분위A조(n=14)화B조(n=20),분별급여0.6 g·kg~(-1)·d~(-1) 화0.8 g·kg~(-1)·d~(-1)단백질섭입량,대량조환자개체화근종지도6개월,측정치료전후인체측량지표급혈생화지표,진행인체영양상황정체평개화24 h선식회고조사.결과 A조치료후혈기항치수평명현하강(P=0.010),백단백수평명현승고(P=0.042),열능(P=0.018)화탄수화합물(P<0.001)적섭입균교치료전명현제고.통과영양간예,정체、A조화B조환자영양불량발생솔비치료전분별하강료14.7%、7.2%화21.1%.결론 0.6 g·kg~(-1)·d~(-1)단백질섭입량급용소맥정분대체부분주식적음식방안가명현제고3/4기CKD환자탄수화합물화열능적섭입량,개선기영양상황화신공능.
Objective To assess the influences of low-protein diet on the renal function and nutritional status in patients with stage 3/4 chronic kidney diseases (CKD).Methods Totally 34 patients with stage 3/4 CKD were randomly divided into group A (protein intake:0.6 g·kg~(-1)·d~(-1);n=14) and B (protein intake:0.8 g·kg~(-1)·d~(-1);n=20).Anthropometric measurement and blood biochemical tests were performed,nutri-tional status was assessed,and 24-hour dietary recall survey was conducted before and after the treatment.Patients were followed up for 6 months.Results In group A,the creatinine level significantly decreased (P=0.010),while albumin level (P=0.042) and the intake of energy (P=0.018) and carbohydrate (P<0.001) signifi-cantly increased after the treatment In all the 34 patients,in group A and group B,the malnutrition rates were de-creased by 14.7%,7.2%,and 21.1% after nutritional intervention.Conclusion The low-protein diet (protein intake 0.6 g·kg~(-1)·d~(-1)),in which part of the staple food was replaced by wheat starch,can increase the in-takes of carbohydrate and energy and improve renal function and nutritional status in patients with stage 3/4 CKD.