中国实验诊断学
中國實驗診斷學
중국실험진단학
CHINESE JOURNAL OF LABORATORY DIAGNOSIS
2009年
7期
891-892
,共2页
赵朝贤%吕英刚%周涛%张园%祝春燕%刘春燕%赵晓唐%贾丽霞%高丽萍
趙朝賢%呂英剛%週濤%張園%祝春燕%劉春燕%趙曉唐%賈麗霞%高麗萍
조조현%려영강%주도%장완%축춘연%류춘연%조효당%가려하%고려평
胆固醇7α-羟化酶%阿尔茨海默病%基因多态性
膽固醇7α-羥化酶%阿爾茨海默病%基因多態性
담고순7α-간화매%아이자해묵병%기인다태성
cholesterol 7α-hydroxylase%Alzheimer's disease%gene polymorphism
目的 探讨胆固醇7α-羟化酶(cholesterol 7α-hydroxylase,CYP7A1)基因多态性与阿尔茨海默病(AD)的关系.方法 用PCR-RFLP方法分析7α-羟化酶A-204C多态性.结果 A-204C多态性基因型频率、等位基因A、C频率在组间比较差异无显著性(P＞0.05),但基因型为CC的AD患者,其TC和LDL-C水平显著高于基因型为AC的AD患者(P＜0.05).结论 7α-羟化酶A-204C多态性与AD无相关性(P＞0.05),但患者组CC基因型与TC、LDL-C水平密切相关(P＜0.01).
目的 探討膽固醇7α-羥化酶(cholesterol 7α-hydroxylase,CYP7A1)基因多態性與阿爾茨海默病(AD)的關繫.方法 用PCR-RFLP方法分析7α-羥化酶A-204C多態性.結果 A-204C多態性基因型頻率、等位基因A、C頻率在組間比較差異無顯著性(P＞0.05),但基因型為CC的AD患者,其TC和LDL-C水平顯著高于基因型為AC的AD患者(P＜0.05).結論 7α-羥化酶A-204C多態性與AD無相關性(P＞0.05),但患者組CC基因型與TC、LDL-C水平密切相關(P＜0.01).
목적 탐토담고순7α-간화매(cholesterol 7α-hydroxylase,CYP7A1)기인다태성여아이자해묵병(AD)적관계.방법 용PCR-RFLP방법분석7α-간화매A-204C다태성.결과 A-204C다태성기인형빈솔、등위기인A、C빈솔재조간비교차이무현저성(P＞0.05),단기인형위CC적AD환자,기TC화LDL-C수평현저고우기인형위AC적AD환자(P＜0.05).결론 7α-간화매A-204C다태성여AD무상관성(P＞0.05),단환자조CC기인형여TC、LDL-C수평밀절상관(P＜0.01).
Objective To study the association of cholesterol 7α-hydroxylase (CYP7A1) gene polymorphism with Alzheimer's disease(AD).Methods cholesterol 7α-hydroxylase genotyping was performed using polymerase chain reaction-restriction fragment polymorphism.Results There was no significant difference in frequencies of allele and genotype in A-204C polymorphism between AD group and control group(P＞0.05).However,the levels of TC and LDL-C in AD patients with CC genotype was higher than that in AD patients with AC genotype(P＜0.05).Conclusion No direct association was found between the A-204C polymorphism and AD,but there is a significant correlation between the CC genotype of the cholesterol 7α-hydroxylase gene and the levels of TC and LDL-C in AD group.
