中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
z1期
1-2
,共2页
曹高健%周瑞耀%黄振丰%李强%林胜璋
曹高健%週瑞耀%黃振豐%李彊%林勝璋
조고건%주서요%황진봉%리강%림성장
三氧化二砷%氟尿嘧啶%吉西他滨%胰腺肿瘤
三氧化二砷%氟尿嘧啶%吉西他濱%胰腺腫瘤
삼양화이신%불뇨밀정%길서타빈%이선종류
Arsenic trioxide%Fluorouracil%Gemcitabine%Pancreatic neoplasms
目的 研究三氧化二砷(As2O3)对人胰腺癌细胞的抑制作用.方法 应用Cell Counting Kit-8法(CCK-8法)测定As2O3对人胰腺癌PC-3细胞株的抑制率,并与氟尿嘧啶(5-Fu)、吉西他滨(GEM)进行比较.结果 与5-Fu、GEM相比,As2O3抑瘤作用最强(P＜0.01或P＜0.05).结论 As2O3体外试验能有效抑制人胰腺癌PC-3细胞株的生长;As2O3对人胰腺癌PC-3细胞株生长的抑制作用强于5-Fu、GEM.As2O3较强的抗胰腺癌细胞能力可能与其广泛而独特的抗癌机制有关.
目的 研究三氧化二砷(As2O3)對人胰腺癌細胞的抑製作用.方法 應用Cell Counting Kit-8法(CCK-8法)測定As2O3對人胰腺癌PC-3細胞株的抑製率,併與氟尿嘧啶(5-Fu)、吉西他濱(GEM)進行比較.結果 與5-Fu、GEM相比,As2O3抑瘤作用最彊(P＜0.01或P＜0.05).結論 As2O3體外試驗能有效抑製人胰腺癌PC-3細胞株的生長;As2O3對人胰腺癌PC-3細胞株生長的抑製作用彊于5-Fu、GEM.As2O3較彊的抗胰腺癌細胞能力可能與其廣汎而獨特的抗癌機製有關.
목적 연구삼양화이신(As2O3)대인이선암세포적억제작용.방법 응용Cell Counting Kit-8법(CCK-8법)측정As2O3대인이선암PC-3세포주적억제솔,병여불뇨밀정(5-Fu)、길서타빈(GEM)진행비교.결과 여5-Fu、GEM상비,As2O3억류작용최강(P＜0.01혹P＜0.05).결론 As2O3체외시험능유효억제인이선암PC-3세포주적생장;As2O3대인이선암PC-3세포주생장적억제작용강우5-Fu、GEM.As2O3교강적항이선암세포능력가능여기엄범이독특적항암궤제유관.
Objective To study the effects of arsenic trioxide ( As2 O3 ) on inhibiting the proliferation of pancreatic carcinoma cell lines. Methods The inhibiting rate of As2O3 and Fluorouracin(5-Fu) ,Gemcitabine(GEM) on pancreatic carcinoma cell lines PC-3 were detected by using CCK-8 assay. Results As compared with 5-Fu、GEM,the inhibiting rate of As2O3 was the highest one( P ＜ 0.01 or P ＜ 0.05). Conclusion As2O3 can inhibit pancreatic carcinoma cell lines PC-3 effectively in vitro. The effects of As2O3 on inhibiting the proliferation of pancreatic carcinoma cell lines was stronger than 5-Fu and GEM. This is possibly due to the extensive and unique anticancer mechanism of As2O3.
