中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2010年
9期
687-690
,共4页
袁成斌%赵任%万方军%蔡建华%季晓频%于颖彦
袁成斌%趙任%萬方軍%蔡建華%季曉頻%于穎彥
원성빈%조임%만방군%채건화%계효빈%우영언
结直肠肿瘤%诊断%网素%基质金属蛋白酶抑制剂
結直腸腫瘤%診斷%網素%基質金屬蛋白酶抑製劑
결직장종류%진단%망소%기질금속단백매억제제
Colorectal neoplasms%Diagnosis%L-plastin%Tissue inhibitor of metalloproteinase
目的 探讨血浆网素(L-plastin)在结直肠癌诊断中的意义.方法 收集2008年3月至2009年3月间40例结直肠癌患者和40例正常人的血浆标本,采用ELISA检测血浆网素浓度,分析其与临床病理资料的关系,并通过与金属基质蛋白酶抑制剂(TIMP-1)进行比较,以评估血浆网素对结直肠癌的诊断价值.结果 肿瘤患者和正常人血浆网素浓度分别为(1.662±0.386) μg/L和(0.485±0.085) μg/L,差异有统计学意义(P＜0.01).网素的理想临界值为0.62 μg/L,其诊断结直肠癌的敏感度为67.5%,特异度为80.6%,曲线下面积(AUC)为0.772,该临界值具有临床判定价值(P＜0.01).血浆网素浓度与肿瘤的大小(P＜0.01)、浆膜穿透(P＜0.05)以及淋巴转移(P＜0.01)有关.TIMP-1诊断结直肠癌的敏感度为70.0%,特异度为60.0%;网素对肿瘤浸润深度判断与TIMP-1相当(8/10比7/10,P＞0.05),但对淋巴结转移的判断则更为准确(86%比58%,P＜0.05).结论 血浆网素水平在结直肠癌患者、尤其是在穿透浆膜和有淋巴结转移的患者中显著升高,具有较高的诊断价值,有望成为判断肿瘤浸润转移的分子标志物.
目的 探討血漿網素(L-plastin)在結直腸癌診斷中的意義.方法 收集2008年3月至2009年3月間40例結直腸癌患者和40例正常人的血漿標本,採用ELISA檢測血漿網素濃度,分析其與臨床病理資料的關繫,併通過與金屬基質蛋白酶抑製劑(TIMP-1)進行比較,以評估血漿網素對結直腸癌的診斷價值.結果 腫瘤患者和正常人血漿網素濃度分彆為(1.662±0.386) μg/L和(0.485±0.085) μg/L,差異有統計學意義(P＜0.01).網素的理想臨界值為0.62 μg/L,其診斷結直腸癌的敏感度為67.5%,特異度為80.6%,麯線下麵積(AUC)為0.772,該臨界值具有臨床判定價值(P＜0.01).血漿網素濃度與腫瘤的大小(P＜0.01)、漿膜穿透(P＜0.05)以及淋巴轉移(P＜0.01)有關.TIMP-1診斷結直腸癌的敏感度為70.0%,特異度為60.0%;網素對腫瘤浸潤深度判斷與TIMP-1相噹(8/10比7/10,P＞0.05),但對淋巴結轉移的判斷則更為準確(86%比58%,P＜0.05).結論 血漿網素水平在結直腸癌患者、尤其是在穿透漿膜和有淋巴結轉移的患者中顯著升高,具有較高的診斷價值,有望成為判斷腫瘤浸潤轉移的分子標誌物.
목적 탐토혈장망소(L-plastin)재결직장암진단중적의의.방법 수집2008년3월지2009년3월간40례결직장암환자화40례정상인적혈장표본,채용ELISA검측혈장망소농도,분석기여림상병리자료적관계,병통과여금속기질단백매억제제(TIMP-1)진행비교,이평고혈장망소대결직장암적진단개치.결과 종류환자화정상인혈장망소농도분별위(1.662±0.386) μg/L화(0.485±0.085) μg/L,차이유통계학의의(P＜0.01).망소적이상림계치위0.62 μg/L,기진단결직장암적민감도위67.5%,특이도위80.6%,곡선하면적(AUC)위0.772,해림계치구유림상판정개치(P＜0.01).혈장망소농도여종류적대소(P＜0.01)、장막천투(P＜0.05)이급림파전이(P＜0.01)유관.TIMP-1진단결직장암적민감도위70.0%,특이도위60.0%;망소대종류침윤심도판단여TIMP-1상당(8/10비7/10,P＞0.05),단대림파결전이적판단칙경위준학(86%비58%,P＜0.05).결론 혈장망소수평재결직장암환자、우기시재천투장막화유림파결전이적환자중현저승고,구유교고적진단개치,유망성위판단종류침윤전이적분자표지물.
Objective To investigate the clinical significance of plasmic L-plastin level in patients with colorectal cancer. Methods From March 2008 to March 2009, plasma samples were collected from 40 patients and 40 healthy controls. Plasmic L-plastin level was measured by ELISA kit and was compared to TIMP-1. Results Plasmic L-plastin level in patients with colorectal cancer was higher than that in healthy adults (1.662±0.386 vs. 0.485±0.085 ?滋g/L,P＜0.01). The sensitivity of L-plastin in the diagnosis of colorectal cancer was 67.5%, and the specificity was 80.6%. The Youden index was 0.481 and AUC was 0.772 (P＜0.01). Plasmic L-plastin levels were associated with the tumor size(P＝0.006), serosal penetration(F＝4.687, P＜0.05) and lymphatic metastasis(P＜0.01). Compared to plasmic TIMP-1 level, L-plastin showed the same capability in indicating the depth of tumor. The specificity of L-plastin was better in indicating lymphatic metastasis (86% vs. 58%, ?字2＝4.2, P＜0.05). Conclusions Plasmic L-plastin level may serve as a potential marker in colorectal cancer.
