CAJ | 학술논문

目的分析硫胺素和核黄素营养状况与机体抗氧化水平及血糖、血脂水平的关系.方法选取上海市区314名中老年人作为调查对象,采用连续三日24小时膳食回顾法计算每日营养素摄入量,尿负荷实验测定机体硫胺素、核黄素营养水平,同时测定其血浆超氧化物歧化酶(SOD)活性、丙二醛(MDA)、空腹血糖(FBG)、总胆固醇(TC)和甘油三酯(TG)水平.结果膳食硫胺素平均摄人量为(0.82 4-0.36)mg/d,其中达到或超过推荐摄入量(RNI)的比例为11.8%,低于60%RNI的比例为51.3%;核黄素平均摄入量为(0.91±0.48)mg/d,其中达到或超过RNI的比例为17.2%,低于60%RNI的比例为49.4%.尿负荷实验结果显示,机体硫胺素缺乏的比例为65.0%,核黄素缺乏的比例为58.6%.与正常组相比,硫胺素、核黄素不足和缺乏组的MDA、FBG、TC和TG水平呈升高趋势,SOD活性呈下降趋势,其中硫胺素缺乏组的MDA、FBG和TC与正常组间差异有统计学意义(P＜0.05).FBG、TC与尿硫胺素水平呈弱负相关(r=-0.246、r=-0.154,P＜0.05),MDA、TG与尿核黄素水平呈弱负相关(r=-0.136、r=-0.297,P＜0.05).结论上海部分地区中老年人硫胺素、核黄素营养水平较低,硫胺素、核黄素营养水平与机体抗氧化水平呈弱正相关趋势,与血糖、血脂水平呈弱负相关趋势.
목적 분석류알소화핵황소영양상황여궤체항양화수평급혈당、혈지수평적관계.방법 선취상해시구314명중노년인작위조사대상,채용련속삼일24소시선식회고법계산매일영양소섭입량,뇨부하실험측정궤체류알소、핵황소영양수평,동시측정기혈장초양화물기화매(SOD)활성、병이철(MDA)、공복혈당(FBG)、총담고순(TC)화감유삼지(TG)수평.결과 선식류알소평균섭인량위(0.82 4-0.36)mg/d,기중체도혹초과추천섭입량(RNI)적비례위11.8%,저우60%RNI적비례위51.3%;핵황소평균섭입량위(0.91±0.48)mg/d,기중체도혹초과RNI적비례위17.2%,저우60%RNI적비례위49.4%.뇨부하실험결과 현시,궤체류알소결핍적비례위65.0%,핵황소결핍적비례위58.6%.여정상조상비,류알소、핵황소불족화결핍조적MDA、FBG、TC화TG수평정승고추세,SOD활성정하강추세,기중류알소결핍조적MDA、FBG화TC여정상조간차이유통계학의의(P＜0.05).FBG、TC여뇨류알소수평정약부상관(r=-0.246、r=-0.154,P＜0.05),MDA、TG여뇨핵황소수평정약부상관(r=-0.136、r=-0.297,P＜0.05).결론 상해부분지구중노년인류알소、핵황소영양수평교저,류알소、핵황소영양수평여궤체항양화수평정약정상관추세,여혈당、혈지수평정약부상관추세.
Objective To investigate the nutrition statuses of thiamine and riboflavin and their relationship with the antioxidant capacity and blood glucose and lipids levels in the middle-aged and elderly. Methods Totally 314 subjects aged above 40 years old from communities in Shanghai were enrolled. The 3-day survey of 24-hour's diet recall was made to evaluate the daily nutrient intakes using a nutrition assessment software provided by CDC China. Thiamine and riboflavin levels were detected by urine load test. Fasting blood glucose ( FBG), total choles-terol (TC), triglyceride (TG), superoxide dismutase (SOD) activity and malondialdehyde (MDA) were deter-mined by commercial kits. Results The average daily intakes of thiamine and riboflavin were (0. 82 + 0. 36) and (0. 91 +0.48) rag, respectively. The middle-aged and elderly whose intakes of thiamine and riboflavin reached recommended nutrient intake (RNI) level accounted for 11.8% and 17.2%, while those lower than 60% RNI ac-counted for 51.3% and 49. 4%, respectively. Urine load test showed the deficiency rates of thiamine and ribofla-vin were 65.0% and 58.6%, respectively. Compared with the normal group, plasma MDA, FBG, TC, and TG levels progressively increased and SOD activity decreased in insufficient and deficient groups; the plasma MDA, FBG, and TC levels were significantly different between normal group and thiamine deficient group ( P < 0. 05 ).The FBG and TC levels were negatively correlated with the status of thiamine ( r = - 0. 246, r = - 0. 154, P <0. 05). The MDA and TG levels were negatively correlated with the status of riboflavin ( r = - 0. 136, r =-0. 297, P <0. 05). Conclusions The nutrition statuses of thiamine and riboflavin are poor in the middle-aged and elderly in Shanghai. The nutritional statuses of thiamine and riboflavin are positively correlated with the antioxi- dant capacities and are negatively correlated with the level of FBG, TC, and TG.