CAJ | 학술논문

目的探讨2型糖尿病(T2DM)、糖调节受损(IGR)和血糖正常(NC)状态下血尿酸(UA)水平与胰岛素抵抗及血脂异常的相关性.方法 94例门诊行空腹胰岛素检测的患者按照糖代谢状态分成T2DM组(45例)、IGR组(20例)、NC组(29例),比较三组血UA和血脂、胰岛素抵抗指数(HOMA-IR)的变化情况.结果在校正年龄、体重指数(BMI)后,T2DM、IGR组的三酰甘油(TG)、血UA水平与NC组相比差异有统计学意义[分别为(3.34±8.77)、(1.85±0.67)、(1.26±0.38)mmol/L和(316.71±96.20)、(403.62±76.80)、(325.45±94.43)mmol/L](P<0.01),T2DM组较NC、IGR组高密度脂蛋白胆固醇(HDL-C)水平明显降低[分别为(1.05±0.30)、(1.12±0.20)、(1.07±0.21)mmol/L](P<0.01);HOMA-IR在T2DM、IGR组与NC组比较差异有统计学意义(中位数分别为3.84、3.77、2.34)(P<0.01);胰岛素敏感指数在T2DM、IGR组明显低于NC组(分别为-4.52±0.79、-4.44±0.19、-4.03±0.58)(P<0.01).相关分析显示血UA水平与BMI、TG呈显著正相关,与HDL-C呈显著负相关.结论高UA血症和脂质代谢紊乱一样,均是T2DM常见的代谢异常;早在IGR期即已出现包括高UA血症在内的多种代谢紊乱,应该给予早期干预.
목적 탐토2형당뇨병(T2DM)、당조절수손(IGR)화혈당정상(NC)상태하혈뇨산(UA)수평여이도소저항급혈지이상적상관성.방법 94례문진행공복이도소검측적환자안조당대사상태분성T2DM조(45례)、IGR조(20례)、NC조(29례),비교삼조혈UA화혈지、이도소저항지수(HOMA-IR)적변화정황.결과 재교정년령、체중지수(BMI)후,T2DM、IGR조적삼선감유(TG)、혈UA수평여NC조상비차이유통계학의의[분별위(3.34±8.77)、(1.85±0.67)、(1.26±0.38)mmol/L화(316.71±96.20)、(403.62±76.80)、(325.45±94.43)mmol/L](P<0.01),T2DM조교NC、IGR조고밀도지단백담고순(HDL-C)수평명현강저[분별위(1.05±0.30)、(1.12±0.20)、(1.07±0.21)mmol/L](P<0.01);HOMA-IR재T2DM、IGR조여NC조비교차이유통계학의의(중위수분별위3.84、3.77、2.34)(P<0.01);이도소민감지수재T2DM、IGR조명현저우NC조(분별위-4.52±0.79、-4.44±0.19、-4.03±0.58)(P<0.01).상관분석현시혈UA수평여BMI、TG정현저정상관,여HDL-C정현저부상관.결론 고UA혈증화지질대사문란일양,균시T2DM상견적대사이상;조재IGR기즉이출현포괄고UA혈증재내적다충대사문란,응해급여조기간예.
Objective To study the levels of senlm uric acid(UA)in normal glucose(NC),impaired glucose regulation(IGR)and type 2 diabetes mellitus(T2DM),and investigate its relationship with insulin resistance and dyslipidemia.Method The levels of blood glucose,lipids,fasting insulin(HNS)and serum UA were measured in patients of 45 T2DM(T2DM group),20 IGR(IGR group)and 29 NC(NC group).Status of insulin resistance and insulin secretion function was evaluated by HOMA-IR and ISI.Results The levels of triglyceride(TG)and UA in T2DM group and IGR group were significantly higher than those in NC group[(3.34±8.77),(1.85±0.67),(1.26±0.38)mmoi/L and(316.71±96.20),(403.62±76.80),(325.45±94.43)mmol/L](P<0.01).HDL-C levels in T2DM group were significantly lower than those in IGR and NC group[(1.05±0.30),(1.07±0.21),(1.12±0.20)mmol/L](P<0.01).NO significant difference of FINS levels was found in the three groups.HOMA-IR level in T2DM and IGR group was higher than that in NC group(3.84,3.77,2.34)(P<0.01).ISI in T2DM and IGR group was lower than that in NC group(-4.52±0.79,-4.44±0.19,-4.03±0.58)(P<0.01).Correlation analysis indicated that the level of UA was positively related with BMI.TG and negatively related with HDL-C.Conclusion Increased UA in IGR indicates that hyperurieacidemia developes before DM.