CAJ | 학술논문

目的研究肾移植患者BK病毒感染的检测方法,并探讨其临床应用价值.方法对132例两院同种异体肾移植随访患者,采集其血、尿标本进行BK病毒的检测,包括:尿沉渣decoy细胞、尿液BKV-DNA和血浆BKV-DNA,确定是否存在BK病毒复制.结果 132例肾移植患者中,37例(28.0%)尿decoy细胞阳性,出现decoy细胞阳性的中位时间为术后12个月;BK病毒尿症32例(24.2%),中位时间为术后11个月;BK病毒血症16例(12.1%),中位时间为术后15个月.5例BK病毒血症患者经病理学证实为BK病毒相关性肾病.结论尿沉渣decoy细胞和体液BKV-DNA检测能早期发现BK病毒感染,为预防肾移植术后BK病毒相关性肾病提供重要的依据.
목적 연구신이식환자BK병독감염적검측방법,병탐토기림상응용개치.방법 대132례량원동충이체신이식수방환자,채집기혈、뇨표본진행BK병독적검측,포괄:뇨침사decoy세포、뇨액BKV-DNA화혈장BKV-DNA,학정시부존재BK병독복제.결과 132례신이식환자중,37례(28.0%)뇨decoy세포양성,출현decoy세포양성적중위시간위술후12개월;BK병독뇨증32례(24.2%),중위시간위술후11개월;BK병독혈증16례(12.1%),중위시간위술후15개월.5례BK병독혈증환자경병이학증실위BK병독상관성신병.결론 뇨침사decoy세포화체액BKV-DNA검측능조기발현BK병독감염,위예방신이식술후BK병독상관성신병제공중요적의거.
Objective To study the detection methods of BK virus infection in kidney transplant recipients, and to explore the clinical application. Methods 132 cases of renal transplant recipients were undertaken BK virus detection including presence of decoy cells in urinary sediment, urine and serum BKVDNA to demonstrate the BK virus replication. Result Among 132 cases of renal transplant recipients,urinary decoy cell was found in 37 (28.0%)patients and the median time was 12 months after surgery. 32(24. 2% )patients were diagnosed as BK viruria at a median of 11 months after surgery, and 16( 12. 1% )recipients were diagnosed as BK viremia at a median of 15 months after surgery, 5 patients with BK viruria were diagnosed as BK virus associated nephropathy according to allograft biopsy. Conclusion To make early diagnosis of BK virus infection, detection of urine decoy cells and BKV-DNA in urine and plasma sample is important,which provides an important basis for the prevention of BK virus associated nephropathy.