CAJ | 학술논문

背景:未分化脊柱关节病命名的提出为强直性脊柱炎和其他脊柱关节病的早期诊断提供了线索,并避免了错误的治疗.目的:了解北京市区某工厂某厂16岁以上职工及家属脊柱关节病患病情况、人类组织相容性复合体B27及骶髂关节X射线平片检查结果.设计:整群抽样调查.单位:汕头市澄海区人民医院内科和汕头大学医学院风湿病学研究室及北京朝阳医院内科.对象:于1999-05/10对北京市区某厂16岁以上职工及家属1 982名进行调查,其中男1 025名,女957名.均对调查项目知情同意,并积极配合.方法:用修订的中国-国际抗风湿联盟风湿病调查表,对调查对象挨户逐人询问,阳性者进行体检,疑似者行类风湿因子、人类组织相容性复合体B27和X射线平片检查.主要观察指标:被调查人群16岁以上职工及家属脊柱关节病患病情况、人类组织相容性复合体B27及骶髂关节X射线平片检查结果.结果:纳入对象1 982名均进入结果分析.脊柱关节病构成比1.61%(32/1 982),其中强直性脊柱炎构成比0.31%(6/1982),未分化脊柱关节病构成比1.21%(24/1982),银屑病性关节炎构成比0.10%(2/1982),未发现其他脊柱关节病.未分化脊柱关节病主要症状为炎症性腰痛和非对称性关节炎[83%(20/24),62%(15/24)],类风湿因子均为阴性,25%(6/24)人类组织相容性复合体B27阳性,男女比例1.2:1.结论:脊柱关节病在北京地区发病构成比为1.61%,其主要构成为强直性脊柱炎和未分化脊柱关节病.
배경:미분화척주관절병명명적제출위강직성척주염화기타척주관절병적조기진단제공료선색,병피면료착오적치료.목적:료해북경시구모공엄모엄16세이상직공급가속척주관절병환병정황、인류조직상용성복합체B27급저가관절X사선평편검사결과.설계:정군추양조사.단위:산두시징해구인민의원내과화산두대학의학원풍습병학연구실급북경조양의원내과.대상:우1999-05/10대북경시구모엄16세이상직공급가속1 982명진행조사,기중남1 025명,녀957명.균대조사항목지정동의,병적겁배합.방법:용수정적중국-국제항풍습련맹풍습병조사표,대조사대상애호축인순문,양성자진행체검,의사자행류풍습인자、인류조직상용성복합체B27화X사선평편검사.주요관찰지표:피조사인군16세이상직공급가속척주관절병환병정황、인류조직상용성복합체B27급저가관절X사선평편검사결과.결과:납입대상1 982명균진입결과분석.척주관절병구성비1.61%(32/1 982),기중강직성척주염구성비0.31%(6/1982),미분화척주관절병구성비1.21%(24/1982),은설병성관절염구성비0.10%(2/1982),미발현기타척주관절병.미분화척주관절병주요증상위염증성요통화비대칭성관절염[83%(20/24),62%(15/24)],류풍습인자균위음성,25%(6/24)인류조직상용성복합체B27양성,남녀비례1.2:1.결론:척주관절병재북경지구발병구성비위1.61%,기주요구성위강직성척주염화미분화척주관절병.
BACKGROUND: The nomination of undifferentiated spondyloarthropathy (USpA) has provided clues for the early diagnosis of spondylitis ankylopoietica and other subsets of SpA, thereby avoiding possible wrong treatments.OBJECTIVE: To investigate the prevalence of SpA in the workers and their adult relatives aged over 16 years old from a factory in Beijing urban district, as well as the results of human major histocompatibility complex (MHC) B27 and X-ray inspection on sacroiliac joint.DESIGN: Systematic sampling investigation.SETTING: Department of Internal Medicine, Chenghai District People's Hospital of Shantou City; Rheumatism Research Institute, Medical College of Shantou University; Department of Internal Medicine, Beijing Chaoyang Hospital.PARTICIPANTS: A survey was conducted among 1982 workers and their adult relatives aged over 16 years from a factory in Beijing urban district between May and October 1999; there were 1,025 males and 957 females.They all volunteered into this study after informed of the experiment.METHODS: All examinees were surveyed door to door with the modified Chinese-International Anti-rheumatic Alliance Rheumatism Questionnaire,those with positive results were subjected to physical examination and those suspicious cases were subjected to MHC-B27 and X-ray examination.MAIN OUTCOME MEASURES: The prevalence of SpA in the workersand their adult relatives aged over 16 years from a factory in Beijing urban district, as well as the results of MHC-B27 and sacroiliac joint X-ray inspection.RESULTS: Totally 1,982 subjects were enrolled in this study and all entered the result analysis. The prevalence of spondyloarthropathy was 1.61%(32/1 982), amongst which the prevalence of ankylopoietic spondylitis,USpA, and psoriastic arthritis was 0.31% (6/1 982), 1.21% (24/1 982),and 0.10% (2/1 982), respectively. No other subsets of SpA were observed. USpA was mainly presented by inflammatory lumbago and asymmetric arthrosteitis [83% (20/24), 62% (15/24)], while rheumatoid factor was negative in all subjects. Meanwhile, MHC-B27 was proved positive in 25% (6/24) subjects with the male-to-female ratio of 1.2:1.CONCLUSION: The prevalence of SpA is 1.61% in Beijing urban area,and SpA mainly consists of ankylopoietic spondylitis and USpA.