上海交通大学学报（医学版）
上海交通大學學報（醫學版）
상해교통대학학보（의학판）
JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY(MEDICAL SCIENCE)
2010年
2期
168-170,185
,共4页
多囊卵巢综合征%炔雌醇环丙孕酮片%胰岛素敏感性%高雄激素血症
多囊卵巢綜閤徵%炔雌醇環丙孕酮片%胰島素敏感性%高雄激素血癥
다낭란소종합정%결자순배병잉동편%이도소민감성%고웅격소혈증
polycystic ovary syndrome%ethinylestradiol and cyproterone acetate tablet%insulin sensitivity%hyperandrogenism
目的 探讨服用炔雌醇环丙孕酮片(商品名:达英-35)对非肥胖型多囊卵巢综合征(PCOS)患者内分泌代谢的影响.方法 53例非肥胖型PCOS患者接受达英-35治疗,持续6个周期.于治疗前及治疗后第3个和第6个周期末,记录体质量指数、腰臀比、多毛评分和痤疮评分;于早卵泡期及治疗后第3个月和第6个月末,测定血清总睾酮、黄体生成素、卵泡刺激素、空腹血糖、空腹胰岛素,计算黄体生成素/卵泡刺激素比值和胰岛素抵抗指数(HOMA-IR).结果 治疗前后患者体质量指数和腰臀比无明显变化;与治疗前比较,治疗后两时间点的多毛评分、痤疮评分、血清总睾酮和黄体生成素水平及黄体生成素/卵泡刺激素比值均显著降低(P<0.05).伴有胰岛素抵抗患者治疗后6个周期末的体质量指数和HOMA-IR明显高于治疗前(P<0.05).结论 短期服用达英-35可明显改善非肥胖型PCOS患者的高雄激素血症.对于同时伴有胰岛素抵抗的非肥胖型PCOS患者,达英-35存在加重其胰岛素抵抗程度的可能.
目的 探討服用炔雌醇環丙孕酮片(商品名:達英-35)對非肥胖型多囊卵巢綜閤徵(PCOS)患者內分泌代謝的影響.方法 53例非肥胖型PCOS患者接受達英-35治療,持續6箇週期.于治療前及治療後第3箇和第6箇週期末,記錄體質量指數、腰臀比、多毛評分和痤瘡評分;于早卵泡期及治療後第3箇月和第6箇月末,測定血清總睪酮、黃體生成素、卵泡刺激素、空腹血糖、空腹胰島素,計算黃體生成素/卵泡刺激素比值和胰島素牴抗指數(HOMA-IR).結果 治療前後患者體質量指數和腰臀比無明顯變化;與治療前比較,治療後兩時間點的多毛評分、痤瘡評分、血清總睪酮和黃體生成素水平及黃體生成素/卵泡刺激素比值均顯著降低(P<0.05).伴有胰島素牴抗患者治療後6箇週期末的體質量指數和HOMA-IR明顯高于治療前(P<0.05).結論 短期服用達英-35可明顯改善非肥胖型PCOS患者的高雄激素血癥.對于同時伴有胰島素牴抗的非肥胖型PCOS患者,達英-35存在加重其胰島素牴抗程度的可能.
목적 탐토복용결자순배병잉동편(상품명:체영-35)대비비반형다낭란소종합정(PCOS)환자내분비대사적영향.방법 53례비비반형PCOS환자접수체영-35치료,지속6개주기.우치료전급치료후제3개화제6개주기말,기록체질량지수、요둔비、다모평분화좌창평분;우조란포기급치료후제3개월화제6개월말,측정혈청총고동、황체생성소、란포자격소、공복혈당、공복이도소,계산황체생성소/란포자격소비치화이도소저항지수(HOMA-IR).결과 치료전후환자체질량지수화요둔비무명현변화;여치료전비교,치료후량시간점적다모평분、좌창평분、혈청총고동화황체생성소수평급황체생성소/란포자격소비치균현저강저(P<0.05).반유이도소저항환자치료후6개주기말적체질량지수화HOMA-IR명현고우치료전(P<0.05).결론 단기복용체영-35가명현개선비비반형PCOS환자적고웅격소혈증.대우동시반유이도소저항적비비반형PCOS환자,체영-35존재가중기이도소저항정도적가능.
Objective To investigate the effects of ethinylestradiol and cyproterone acetate tablets(Diane-35)on endocrine metabolism in non-obese women with polycystic ovary syndrome(PCOS). Methods Fifty-three non-obese patients with PCOS were assigned to the 6-month treatment with Diane-35.Body mass index(BMI),waist to hip ratio(WHR),F-G score and acne score were recorded before treatment and at the end of the third and sixth cycle after treatment.Serum total testosterone,follicle stimulating hormone(FSH),luteinizing hormone(LH),LH/FSH,fast plasma glucose,fast insulin and insulin resistance index(HOMA-IR)were obtained at early follicular phase and at the end of the third and sixth month.Results There was no significant change in BMI and WHR after treatment.Compared with those before treatment.F-G score,acne score,serum total testosterone,LH and LH/FSH were significantly decreased at two time points after treatment (P<0.05).BMI and HOMA-IR in patients with insulin resistance were significantly higher at the end of the sixth cycle after treatment than those before treatment(P<0.05). Conclusion Diane-35 can improve hyperandrogenism in non-obese patients with PCOS.However,Diane-35 may aggravate insulin resistance in those with insulin resistance.
