中国老年学杂志
中國老年學雜誌
중국노년학잡지
CHINESE JOURNAL OF GERONTOLOGY
2010年
3期
342-344
,共3页
卜淑敏%陈永杰%王颖捷%郝利科
蔔淑敏%陳永傑%王穎捷%郝利科
복숙민%진영걸%왕영첩%학리과
运动%去卵巢大鼠%骨密度%性激素
運動%去卵巢大鼠%骨密度%性激素
운동%거란소대서%골밀도%성격소
Exercise%Ovariectomized rats%Bone mineral density%Sex hormones
目的 观察中等强度跑台运动对去卵巢大鼠骨量和相关血清性激素水平的影响,探讨其预防绝经后骨质疏松发生的作用机制.方法 40只未经产雌性SD大鼠,按体重随机分为假手术、去卵巢静止、去卵巢运动和雌激素4组.去卵巢运动组每周进行4次45 min、速度18 m/min,坡度5°的跑台训练;雌激素组每周颈部皮下注射3次17β-雌二醇,每次50 μg/kg体重.结束后,称量腹腔内脂肪和子宫重量;测定血清雌激素(E_2)、孕酮(P_4) 和睾酮(T)含量;检测右侧游离股骨和胫骨的骨密度(BMD)和骨矿物(BMC) 含量.结果 中等强度跑台运动能显著增加去卵巢大鼠股骨近端、中段和远端以及胫骨近端的BMC、BMD以及血清E_2水平,显著降低去卵巢大鼠腹腔内脂肪重量以及血清P4和T水平.结论 中等强度跑台运动抗去卵巢大鼠骨量下降的效应至少部分可能与其对血清性激素水平的调节有关.
目的 觀察中等彊度跑檯運動對去卵巢大鼠骨量和相關血清性激素水平的影響,探討其預防絕經後骨質疏鬆髮生的作用機製.方法 40隻未經產雌性SD大鼠,按體重隨機分為假手術、去卵巢靜止、去卵巢運動和雌激素4組.去卵巢運動組每週進行4次45 min、速度18 m/min,坡度5°的跑檯訓練;雌激素組每週頸部皮下註射3次17β-雌二醇,每次50 μg/kg體重.結束後,稱量腹腔內脂肪和子宮重量;測定血清雌激素(E_2)、孕酮(P_4) 和睪酮(T)含量;檢測右側遊離股骨和脛骨的骨密度(BMD)和骨礦物(BMC) 含量.結果 中等彊度跑檯運動能顯著增加去卵巢大鼠股骨近耑、中段和遠耑以及脛骨近耑的BMC、BMD以及血清E_2水平,顯著降低去卵巢大鼠腹腔內脂肪重量以及血清P4和T水平.結論 中等彊度跑檯運動抗去卵巢大鼠骨量下降的效應至少部分可能與其對血清性激素水平的調節有關.
목적 관찰중등강도포태운동대거란소대서골량화상관혈청성격소수평적영향,탐토기예방절경후골질소송발생적작용궤제.방법 40지미경산자성SD대서,안체중수궤분위가수술、거란소정지、거란소운동화자격소4조.거란소운동조매주진행4차45 min、속도18 m/min,파도5°적포태훈련;자격소조매주경부피하주사3차17β-자이순,매차50 μg/kg체중.결속후,칭량복강내지방화자궁중량;측정혈청자격소(E_2)、잉동(P_4) 화고동(T)함량;검측우측유리고골화경골적골밀도(BMD)화골광물(BMC) 함량.결과 중등강도포태운동능현저증가거란소대서고골근단、중단화원단이급경골근단적BMC、BMD이급혈청E_2수평,현저강저거란소대서복강내지방중량이급혈청P4화T수평.결론 중등강도포태운동항거란소대서골량하강적효응지소부분가능여기대혈청성격소수평적조절유관.
Objective To observe the effects of moderate-intensity treadmill exercise on bone mass and related serum sex hormones in ovariectomized rats. Methods Forty 3-month-old female SD rats were either sham-operated (SHAM) or ovariectomized (OVX) and randomly divided into four groups by body weight: SHAM, OVX, OVX rats treated with exercise (EX group, 18 m/min, 5% uphill, 45 min/day, 4 times/week), OVX rats treated with 17β-estrogen groups (E2 group, 50 μg/kg once, 3 times/w). At the end of the experiment, blood was collected from abdominal vein with general anesthesia. The levels of serum E2, progesterone (P4), and testosterone (T) as well as the BMC and BMD of right femur and tibia were measured. Results The BMC and BMD in all three sites of femur and proximal tibia as well as the serum E2 level were increased remarkably in EX group compared with those of OVX group. However, the abdominal fat weight, the levels of serum P4 and T were decreased significantly while no change was found in uterus index between the OVX group and EX group. Conclusions The anti-osteopenia activity of moderate treadmill exercise in OVX rats may be at least partially connected with sex hormones.