CAJ | 학술논문

SIRT1是一种NAD+依赖的组蛋白脱乙酰基蛋白酶,参与体内众多蛋白酶和转录因子的活性调节.在哺乳动物中,SIRT1促进脂肪动员、脂肪酸氧化、葡萄糖产生和胰岛素分泌.SIRT1激动剂可明显改善机体的胰岛素敏感性,降低血浆葡萄糖水平.因此,SIRT1激动剂的使用将可能成为2型糖尿病的新的治疗途径.
SIRT1시일충NAD+의뢰적조단백탈을선기단백매,삼여체내음다단백매화전록인자적활성조절.재포유동물중,SIRT1촉진지방동원、지방산양화、포도당산생화이도소분비.SIRT1격동제가명현개선궤체적이도소민감성,강저혈장포도당수평.인차,SIRT1격동제적사용장가능성위2형당뇨병적신적치료도경.
SIRT1,a NAD+ -dependent deacetylase,regulates activity of many proteases and transcription factors in vivo.In mammals,S1RT1 promotes fat mobilization,fatty acid oxidation,glucose production,and insulin secretion.Some small molecule activators of SIRT1 impmve insulin sensitivity and reduce plasma glucose significantly.Accordingly,SIRT1 activation is a promising new therapeutic approach for treatingtype 2 diabetes.