中华放射肿瘤学杂志
中華放射腫瘤學雜誌
중화방사종류학잡지
CHINESE JOURNAL OF RADIATION ONCOLOGY
2011年
4期
351-354
,共4页
孙明霞%李洪振%高献书%秦尚彬%刘朝兴%张敏%赵静%李晓梅%赵玉亮
孫明霞%李洪振%高獻書%秦尚彬%劉朝興%張敏%趙靜%李曉梅%趙玉亮
손명하%리홍진%고헌서%진상빈%류조흥%장민%조정%리효매%조옥량
洛铂%顺铂%放射增敏%肿瘤移植%小鼠
洛鉑%順鉑%放射增敏%腫瘤移植%小鼠
락박%순박%방사증민%종류이식%소서
Lobaplatin%Cisplatin%Radiosensitization%Neoplasm transplantation%Mice
目的 了解顺铂、洛铂给药后不同时间照射对小鼠肺癌移植瘤的放射增敏作用影响.方法 70只C57BL/6近交系Lewis肺癌移植小鼠随机分组,按10 mg药物/kg体重经尾静脉分别注射顺铂和洛铂,给药后在0.5、2.0、4.0、24.0、48.0、72.0、96.0 h分别将小鼠处死获取肿瘤组织标本,应用ICP-MS方法测定标本铂含量.80只荷瘤小鼠随机分为对照、单纯药物、单纯照射、药物联合照射组共10个组,注射药物后1、24 h或72 h对肿瘤局部进行照射,比较各组间肿瘤大小.结果 顺铂、洛铂在肿瘤组织浓度均在给药后迅速达到4.78、2.79 μg/g (t=3.82,P=0.005),4 h后分别降至3.39、0.99 μg/g (t=9.10,P=0.000),96 h时分别为1.41、0.23 μg/g (t=3.70,P=0.006).顺铂给药后1、24、72 h照射组之间肿瘤生长速度相似,但比对照组、单纯照射组、单纯顺铂组均明显变缓;在第15天时肿瘤相对体积分别为4.73、5.52、2.15(F=0.84,P=0.451),而对照组、单纯照射组、单纯顺铂组分别为16.63(F=10.50,P=0.000)、10.34(F=3.12,P=0.046)、12.80(F=8.06,P=0.001).洛铂给药后1、24、72 h照射组之间肿瘤生长速度也相似,但与对照组、单纯照射组、单纯洛铂组相比均明显变缓;在第15天时肿瘤相对体积分别为3.49、4.90、3.86(F=0.32,P=0.727),而对照组、单纯照射组、单纯洛铂组分别为16.63(F=15.21,P=0.000)、10.34(F=4.12,P=0.016)、14.28(F=10.67,P=0.000).顺铂和洛铂在1、24、72 h的放射增敏比分别为2.13、2.03、3.45和2.53、2.00、2.50.结论 顺铂一次给药后肿瘤内药物浓度至少能持续96 h,其放射增敏作用能持续较长时间;洛铂具有与顺铂相似的抗肿瘤效果及放射增敏作用.
目的 瞭解順鉑、洛鉑給藥後不同時間照射對小鼠肺癌移植瘤的放射增敏作用影響.方法 70隻C57BL/6近交繫Lewis肺癌移植小鼠隨機分組,按10 mg藥物/kg體重經尾靜脈分彆註射順鉑和洛鉑,給藥後在0.5、2.0、4.0、24.0、48.0、72.0、96.0 h分彆將小鼠處死穫取腫瘤組織標本,應用ICP-MS方法測定標本鉑含量.80隻荷瘤小鼠隨機分為對照、單純藥物、單純照射、藥物聯閤照射組共10箇組,註射藥物後1、24 h或72 h對腫瘤跼部進行照射,比較各組間腫瘤大小.結果 順鉑、洛鉑在腫瘤組織濃度均在給藥後迅速達到4.78、2.79 μg/g (t=3.82,P=0.005),4 h後分彆降至3.39、0.99 μg/g (t=9.10,P=0.000),96 h時分彆為1.41、0.23 μg/g (t=3.70,P=0.006).順鉑給藥後1、24、72 h照射組之間腫瘤生長速度相似,但比對照組、單純照射組、單純順鉑組均明顯變緩;在第15天時腫瘤相對體積分彆為4.73、5.52、2.15(F=0.84,P=0.451),而對照組、單純照射組、單純順鉑組分彆為16.63(F=10.50,P=0.000)、10.34(F=3.12,P=0.046)、12.80(F=8.06,P=0.001).洛鉑給藥後1、24、72 h照射組之間腫瘤生長速度也相似,但與對照組、單純照射組、單純洛鉑組相比均明顯變緩;在第15天時腫瘤相對體積分彆為3.49、4.90、3.86(F=0.32,P=0.727),而對照組、單純照射組、單純洛鉑組分彆為16.63(F=15.21,P=0.000)、10.34(F=4.12,P=0.016)、14.28(F=10.67,P=0.000).順鉑和洛鉑在1、24、72 h的放射增敏比分彆為2.13、2.03、3.45和2.53、2.00、2.50.結論 順鉑一次給藥後腫瘤內藥物濃度至少能持續96 h,其放射增敏作用能持續較長時間;洛鉑具有與順鉑相似的抗腫瘤效果及放射增敏作用.
목적 료해순박、락박급약후불동시간조사대소서폐암이식류적방사증민작용영향.방법 70지C57BL/6근교계Lewis폐암이식소서수궤분조,안10 mg약물/kg체중경미정맥분별주사순박화락박,급약후재0.5、2.0、4.0、24.0、48.0、72.0、96.0 h분별장소서처사획취종류조직표본,응용ICP-MS방법측정표본박함량.80지하류소서수궤분위대조、단순약물、단순조사、약물연합조사조공10개조,주사약물후1、24 h혹72 h대종류국부진행조사,비교각조간종류대소.결과 순박、락박재종류조직농도균재급약후신속체도4.78、2.79 μg/g (t=3.82,P=0.005),4 h후분별강지3.39、0.99 μg/g (t=9.10,P=0.000),96 h시분별위1.41、0.23 μg/g (t=3.70,P=0.006).순박급약후1、24、72 h조사조지간종류생장속도상사,단비대조조、단순조사조、단순순박조균명현변완;재제15천시종류상대체적분별위4.73、5.52、2.15(F=0.84,P=0.451),이대조조、단순조사조、단순순박조분별위16.63(F=10.50,P=0.000)、10.34(F=3.12,P=0.046)、12.80(F=8.06,P=0.001).락박급약후1、24、72 h조사조지간종류생장속도야상사,단여대조조、단순조사조、단순락박조상비균명현변완;재제15천시종류상대체적분별위3.49、4.90、3.86(F=0.32,P=0.727),이대조조、단순조사조、단순락박조분별위16.63(F=15.21,P=0.000)、10.34(F=4.12,P=0.016)、14.28(F=10.67,P=0.000).순박화락박재1、24、72 h적방사증민비분별위2.13、2.03、3.45화2.53、2.00、2.50.결론 순박일차급약후종류내약물농도지소능지속96 h,기방사증민작용능지속교장시간;락박구유여순박상사적항종류효과급방사증민작용.
Objective To learn the effect of different combination model between irradiation and cisplatin or lobaplatin on the radiosensitization of xenographt tumor in mice.Methods Seventy C57BL/6 mice with Lewis lung carcinoma were randomly divided into fourteen groups.Then a single intravenous bolus injection of 10 mg/kg either cisplatin or lobaplatin was given.Tumor tissues were collected at the indicated times of 0.5 h, 2.0 h, 4.0 h, 24.0 h, 48.0 h, 72.0 h, and 96.0 h.The platinum levels were determined by inductively coupled plasma-mass spectrometry.Eighty tumor-bearing mice were randomly divided into 10 groups, including a blank control group, a irradiation group, two drug treatment groups and 6 combined treatment groups.The tumors were irradiated at 1 h, 24 h or 72 h after either cisplatin or lobaplatin injection.The tumor size of the groups was compared.Results The concentrations of cisplatin and lobaplatin in tumors rapidly reached 4.78 μg/g and 2.79 μg/g (t=3.82,P=0.005), respectively, then declined rapidly to 3.39 μg/g and 0.99 μg/g (t=9.10,P=0.000) at 4 h, 1.41 μg/g and 0.23 μg/g (t=3.70,P=0.006) at 96 h, respectively.The tumor growth among the three groups of irradiation at 1 h, 24 h or 72 h after cisplatin was similar, which was slower than the blank control group, the irradiation group and the cisplatin treatment group.At the 15th day, the relative volume of tumor in the three combined treatment groups were 4.73, 5.52 and 2.15(F=0.84,P=0.451), While was 16.63(F=10.50,P=0.000) in the blank control group, 10.34(F=3.12,P=0.046) in the irradiation group, and 12.80(F=8.06,P=0.001) in the cisplatin treatment group, respectively.The tumor growth among the three groups of irradiation at 1 h, 24 h or 72 h after lobaplatin was also similar, which was slower than the blank control group, the irradiation group and the lobaplatin treatment group.At the 15th day, the relative volume of tumor in the three combined treatment groups were 3.49, 4.90 and 3.86(F=0.32,P=0.727), While was 16.63(F=15.21,P=0.000) in the blank control group, 10.34(F=4.12,P=0.016) in the irradiation group, and 14.28(F=10.67,P=0.000) in the lobaplatin treatment group, respectively.The sensitizing enhancement ratio (SER) at 1 h, 24 h and 72 h after the injection were 2.13, 2.03 and 3.45 of cisplatin, and 2.53, 2.00 and 2.50 of lobaplatin, respectively.Conclusions After intravenous bolus injection, the cisplatin concentration in the tumor can be kept at least 96 hours, which results in a persistent radiosensitizing effect.Lobaplatin and cisplatin have similar anti-tumor and radiosensitizing effect.