国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
9期
1227-1229
,共3页
季兵%关健华%陈先明%谢政权%林靖%高飞
季兵%關健華%陳先明%謝政權%林靖%高飛
계병%관건화%진선명%사정권%림정%고비
2型糖尿病/中西医结合疗法%初诊%胰岛素抵抗/药物作用%滋阴清热
2型糖尿病/中西醫結閤療法%初診%胰島素牴抗/藥物作用%滋陰清熱
2형당뇨병/중서의결합요법%초진%이도소저항/약물작용%자음청열
Type 2 diabetes mellitus/Combination therapy with TCM and Western medicin%Newly diagnosed%Insulin resistance/Action of medication%Nourishing yin and clearing heat
目的 观察中医滋阴清热法改善初诊2型糖尿病胰岛素抵抗状态的疗效.方法 将40例新诊断2型糖尿病患者随机分成两组,其中治疗组20例,对照组20例.治疗组给予胰岛素泵强化治疗加服滋阴清热方(由生地、玄参、麦冬、生石膏、知母、葛根、天花粉、黄连、枳实等组成),对照组单纯采用胰岛素泵强化治疗;血糖控制目标:空腹血糖( FBG)<6.1 mmol/L,餐后血糖(PBG)<8.0 mmol/L,维持2周.观察两组中医证候、空腹血糖及胰岛素、餐后2h血糖、血脂、血流变、胰岛素抵抗指数等变化,记录胰岛素用量、血糖达标时间.结果 治疗组中医证候疗效明显优于对照组(P< 0.05).治疗组Ins平均用量比对照组少,血糖达标时间比对照组快(P<0.05).治疗过程中除了少数患者出现低血糖反应,均未出现其他明显不良反应.结论中西医结合治疗初诊2型糖尿病有效,在改善胰岛素抵抗方面中药具有一定的优势,同时胰岛素的用量更少,血糖达标更快、更平稳.
目的 觀察中醫滋陰清熱法改善初診2型糖尿病胰島素牴抗狀態的療效.方法 將40例新診斷2型糖尿病患者隨機分成兩組,其中治療組20例,對照組20例.治療組給予胰島素泵彊化治療加服滋陰清熱方(由生地、玄參、麥鼕、生石膏、知母、葛根、天花粉、黃連、枳實等組成),對照組單純採用胰島素泵彊化治療;血糖控製目標:空腹血糖( FBG)<6.1 mmol/L,餐後血糖(PBG)<8.0 mmol/L,維持2週.觀察兩組中醫證候、空腹血糖及胰島素、餐後2h血糖、血脂、血流變、胰島素牴抗指數等變化,記錄胰島素用量、血糖達標時間.結果 治療組中醫證候療效明顯優于對照組(P< 0.05).治療組Ins平均用量比對照組少,血糖達標時間比對照組快(P<0.05).治療過程中除瞭少數患者齣現低血糖反應,均未齣現其他明顯不良反應.結論中西醫結閤治療初診2型糖尿病有效,在改善胰島素牴抗方麵中藥具有一定的優勢,同時胰島素的用量更少,血糖達標更快、更平穩.
목적 관찰중의자음청열법개선초진2형당뇨병이도소저항상태적료효.방법 장40례신진단2형당뇨병환자수궤분성량조,기중치료조20례,대조조20례.치료조급여이도소빙강화치료가복자음청열방(유생지、현삼、맥동、생석고、지모、갈근、천화분、황련、지실등조성),대조조단순채용이도소빙강화치료;혈당공제목표:공복혈당( FBG)<6.1 mmol/L,찬후혈당(PBG)<8.0 mmol/L,유지2주.관찰량조중의증후、공복혈당급이도소、찬후2h혈당、혈지、혈류변、이도소저항지수등변화,기록이도소용량、혈당체표시간.결과 치료조중의증후료효명현우우대조조(P< 0.05).치료조Ins평균용량비대조조소,혈당체표시간비대조조쾌(P<0.05).치료과정중제료소수환자출현저혈당반응,균미출현기타명현불량반응.결론중서의결합치료초진2형당뇨병유효,재개선이도소저항방면중약구유일정적우세,동시이도소적용량경소,혈당체표경쾌、경평은.
Objective To observe the efficacy of Chinese therapy with nourishing yin and clearing heat treatment combined with insulin pump in the treatment of newly diagnosed patients with type 2 diabetes mellitus.Methods 40 patients were ramdomly assigned to receive Chinese therapy with nourishing yin and clearing heat ( formula with rehmannia,figwort root,ophiopogon japonicus,gypsum,rhizoma anemarrhenae,radix puerariae,radix trichosanthis,coptis chinensis franch,and immature bitter orange ) combined with insulin pump ( 20 patients,study group ),or insulin pump alone ( 20 patients,control group ).The target of blood glucose control was FBG < 6.1mmol/L and PBG < 8.0 mmol/L for 2 weeks.Syndromes,FBG,FINS,2hPG,TC,TG,Blood rheology,and HOMA-IR were compared between the two groups.The dosage of insulin use and time to standard glucose level were noted.Results The study group was superior to the control group in improvement of syndromes,with a significant difference ( P < 0.05 ).FBG,2hPG,FINS,and HOMA-IR were reduced significantly after combination therapy( P< 0.05 ),and HOMA-IR was significantly reduced in the study group,as compared to the control group ( P< 0.05 ).Both dosage of insulin use was smaller and time to standard glucose level were shorter in the study group than in the control group.No obvious adverse reactions occurred except hypoglycemia in few patients.Conclusions Combination therapy with TCM and Western medicine for newly diagnosed type 2 diabetes mellitus is effective.There are some advantages in reducing insulin resistance with less use of insulin.