CAJ | 학술논문

目的应用频域相干光断层扫描(OCT)技术评价Stargardt病患者黄斑区视网膜容积与中心视力之间的关系.方法回顾性病例系列研究.收集10例(20只眼)Stargardt病的临床资料进行回顾性分析.所有患者均使用频域OCT分别测量黄斑中心凹区视网膜厚度、黄斑中心凹区光感受器细胞内外节缺失宽度、黄斑中心凹区直径3 mm和1 mm范围内的视网膜容积.运用线性回归分析法,比较最小分辨角对数(logMAR)视力与黄斑中心凹区视网膜厚度、黄斑中心凹区光感受器细胞内外节(IS/OS)缺失宽度、黄斑中心凹区直径3 mm和1 mm范围内视网膜容积的关系.结果 18只眼的logMAR视力为0.30～1.22,黄斑中心凹区光感受器细胞内外节缺失宽度为847～5306μm,黄斑中心凹区视网膜厚度为20～126 μm,黄斑中心凹区直径3 mm和1 mm范围内的视网膜容积分别为1.06～1.76 mm3、0.06～0.13 mm3.logMAR视力与黄斑中心凹区光感受器细胞内外节缺失宽度呈正相关(r=0.695,P＜0.05),与黄斑中心凹区视网膜厚度呈负相关(r=-0.601,P＜0.05),与黄斑中心凹区直径3 mm范围内的视网膜容积呈负相关(r=-0.725,P＜0.05),与黄斑中心凹区直径1 mm范围内的视网膜容积无相关性(r=-0.364,P＜0.05).结论频域OCT技术可以清晰观察Stargardt 病患者各层视网膜结构,频域OCT检测获得的黄斑区视网膜容积与中心视力间存在一定的相关性.
목적 응용빈역상간광단층소묘(OCT)기술평개Stargardt병환자황반구시망막용적여중심시력지간적관계.방법 회고성병례계렬연구.수집10례(20지안)Stargardt병적림상자료진행회고성분석.소유환자균사용빈역OCT분별측량황반중심요구시망막후도、황반중심요구광감수기세포내외절결실관도、황반중심요구직경3 mm화1 mm범위내적시망막용적.운용선성회귀분석법,비교최소분변각대수(logMAR)시력여황반중심요구시망막후도、황반중심요구광감수기세포내외절(IS/OS)결실관도、황반중심요구직경3 mm화1 mm범위내시망막용적적관계.결과 18지안적logMAR시력위0.30～1.22,황반중심요구광감수기세포내외절결실관도위847～5306μm,황반중심요구시망막후도위20～126 μm,황반중심요구직경3 mm화1 mm범위내적시망막용적분별위1.06～1.76 mm3、0.06～0.13 mm3.logMAR시력여황반중심요구광감수기세포내외절결실관도정정상관(r=0.695,P＜0.05),여황반중심요구시망막후도정부상관(r=-0.601,P＜0.05),여황반중심요구직경3 mm범위내적시망막용적정부상관(r=-0.725,P＜0.05),여황반중심요구직경1 mm범위내적시망막용적무상관성(r=-0.364,P＜0.05).결론 빈역OCT기술가이청석관찰Stargardt 병환자각층시망막결구,빈역OCT검측획득적황반구시망막용적여중심시력간존재일정적상관성.
Objective To assess the relationship between central visual acuity and retinal volume of macular fovea in patients with Stargardt disease by spectral-domain optical coherence tomography ( SD OCT). Methods It was a retrospective case series study. Twenty eyes of 10 patients with Stargardt disease were investigated by three-dimensional spectral-domain optical coherence tomography. SD OCT images were obtained and retrospectively analyzed. The retinal volumes of macular fovea were measured by SD OCT,whose diameters were set as 3 mm and 1 mm separately ( volume 3 and volume 1). The retinal thickness of macular fovea (macular thickness) and the width of IS/OS conjunction loss of macular fovea (IS/OS loss)were also measured by SD OCT. We correlated the logMAR BCVA with IS/OS loss, macular thickness,volume 3 and volume 1 by linear regression analysis. Results LogMAR BCVA was from 0. 3 to 1. 22.IS/OS loss was from 847 μm to 5306 μm. Macular thickness was from 20 μm to 126μm. Volume 3 and volume 1 was from 1. 06 to 1. 76 mm3 and 0. 06 to 0. 13 mm3. LogMAR BCVA correlated with the IS/OS loss (r = 0.695,P＜0. 05) , macular thickness (r= - 0. 601 ,P ＜ 0. 05), and volume 3 ( r = -0.725,P＜0. 05 ). LogMAR BCVA did not correlate with volume 1 ( r = - 0. 364, P ＞ 0. 05). Conclusions SD OCT could demonstrate the retinal structure of Stargardt disease clearly. The retinal volume of macular fovea accessed by SD OCT correlated with the visual acuity of Stargardt disease.