CAJ | 학술논문

糖尿病视网膜病变(DR)发病机制和药物治疗的研究依赖于动物疾病模型.目前,糖尿病动物模型有药物或饮食诱发性、转基因或基因敲除、自发性遗传性和氧诱导性4种类型.其中链脲佐菌素诱导的糖尿病大鼠模型,因其周期短、成本低和重复性好最为常用.但尚无可用的能复制出人类非增殖性和增殖性DR所有血管性和神经性病变的糖尿病动物模型,甚至一些糖尿病动物模型不能出现非增殖性DR的典型病变.而且,造模后能产生视网膜病变的类型和严重程度,与动物的种属、寿命、病程及造模方法有关.因此,研究者应明确不同类型动物模型各自的特征和局限性,根据研究目的和资源等因素,选择合适的动物模型.尤其应审慎的是,动物实验的结果并非完全符合人类的疾病特征.
당뇨병시망막병변(DR)발병궤제화약물치료적연구의뢰우동물질병모형.목전,당뇨병동물모형유약물혹음식유발성、전기인혹기인고제、자발성유전성화양유도성4충류형.기중련뇨좌균소유도적당뇨병대서모형,인기주기단、성본저화중복성호최위상용.단상무가용적능복제출인류비증식성화증식성DR소유혈관성화신경성병변적당뇨병동물모형,심지일사당뇨병동물모형불능출현비증식성DR적전형병변.이차,조모후능산생시망막병변적류형화엄중정도,여동물적충속、수명、병정급조모방법유관.인차,연구자응명학불동류형동물모형각자적특정화국한성,근거연구목적화자원등인소,선택합괄적동물모형.우기응심신적시,동물실험적결과병비완전부합인류적질병특정.
Animal models of diabetes mellitus ( DM ) are vital for research on pathogenesis and pharmaceutical therapy of diabetic retinopathy(DR).At present,diabetic animal models include chemicals or dietary-induced models,transgenic or gene knockout mice,and spontaneous mice,etc.Among these models,rat model induced by streptozotocin is simple and imminent with high repeatability,which made it the most popular one. However,no available diabetic model could reproduce all vascular and neural pathological changes observed in human non-proliferative and proliferative DR.It is also known that not all DM models could lead to DR.In addition,features and severity of retinopathy in the model depend on animal kinds,animal lifespan,time course of the disease and induction methods.Therefore,researchers should consider characteristics and limitations of different models while choosing suitable DM model based on research objectives and resources.It is particularly emphasized that the results from animal models do not always fit human conditions.