CAJ | 학술논문

目的对全身56例血管平滑肌脂肪瘤(AML)进行分类,探讨其各个组织亚型的临床病理及免疫组织化学特点.方法对全身56例AML患者进行临床病理回顾性分析,并进行组织亚型分类及免疫组织化学检查.结果 56例AML中,发生在肾脏43例,发生在肝脏9例,发生在腹膜后3例,发生在结肠1例.三相型43/56(76.9%);单相型6/56(10.7%);上皮样型6/56(10.7%);AML伴上皮囊肿1/56(1.7%).免疫组织化学染色显示:55例(98.2%)表达HMB45,54例(96.4%)表达Melan-A,28例(50.0%)表达CD1a,Ki-67的表达比例不一,CD34全部呈阴性表达.结论 AML可分为4种组织类型但诊断免疫标记相似,特征性表达HMB45、Melan-A、CD1a,手术效果均好.
목적 대전신56례혈관평활기지방류(AML)진행분류,탐토기각개조직아형적림상병리급면역조직화학특점.방법 대전신56례AML환자진행림상병리회고성분석,병진행조직아형분류급면역조직화학검사.결과 56례AML중,발생재신장43례,발생재간장9례,발생재복막후3례,발생재결장1례.삼상형43/56(76.9%);단상형6/56(10.7%);상피양형6/56(10.7%);AML반상피낭종1/56(1.7%).면역조직화학염색현시:55례(98.2%)표체HMB45,54례(96.4%)표체Melan-A,28례(50.0%)표체CD1a,Ki-67적표체비례불일,CD34전부정음성표체.결론 AML가분위4충조직류형단진단면역표기상사,특정성표체HMB45、Melan-A、CD1a,수술효과균호.
Objective To investigate the clinicopathological and immunohistochemical characteristics of angiomyolipoma (AML) subtypes. Methods A retrospective study was done by subclassifying the 56 cases of AML, and clinicopathological investigation and immunohistochemical staining were also performed. Results Among the 56 cases, 43 eases were developed in the kidney, 9 cases in the liver, 3 eases in the retroperitoneal space, and one case in the colon. Forty-three cases (43/56, 76.9% ) were at tributed to the triphasic subtype, 6 cases (6/56, 10. 7%) to monophasic subtype, 6 cases (6/56,10. 7% ) to epithelioid subtype, and one case ( 1/56, 1.7% ) to AML with epithelial cyst formation. Immunohistochemically, 55 cases (55/56, 98.2% ) were positive for HMB45, 54 cases (54/56, 96. 4% )for Melan-A, and 28 cases (28/56, 50. 0% ) for CD1a. The expression rate of Ki-67 was variable case by case. GD34 was always negative. Conclusion The AMLs could be subclassified into 4 subtypes with the similar immunostaining labels including HMB45, Melan-A, and CD1 a. The outcome of AML is always good after surgical therapy.