CAJ | 학술논문

目的制备表阿霉素聚氰基丙烯酸正丁酯磁性纳米粒(EPI-PBCA-MNPs)并进行表征.方法以化学共沉淀法制得粒径(15.2±4.6)am的Fe3O4纳米磁流体,采用微乳液反相界面聚合法制得EPI-PBCA-MNPs,反应条件:pH=2.0,搅拌速度2000 r/min,然后对其进行相关表征.结果 EPI-PBCA-MNPS粒径为(152.0 ±28.5)nm,分布均匀,胶体溶液长期稳定,平均包封率为(81.30 ±15.20)%,平均载药量为(14.65±2.05)%,饱和磁化强度为:0.35 KA/m.结论制备的EPI-PBCA-MNPs粒径合适,分布均匀,其主要指标符合肝癌靶向治疗的要求.
목적 제비표아매소취청기병희산정정지자성납미립(EPI-PBCA-MNPs)병진행표정.방법 이화학공침정법제득립경(15.2±4.6)am적Fe3O4납미자류체,채용미유액반상계면취합법제득EPI-PBCA-MNPs,반응조건:pH=2.0,교반속도2000 r/min,연후대기진행상관표정.결과 EPI-PBCA-MNPS립경위(152.0 ±28.5)nm,분포균균,효체용액장기은정,평균포봉솔위(81.30 ±15.20)%,평균재약량위(14.65±2.05)%,포화자화강도위:0.35 KA/m.결론 제비적EPI-PBCA-MNPs립경합괄,분포균균,기주요지표부합간암파향치료적요구.
Objective To prepare and characterize epirubicin polybutylcyanoacrylate magnetic nanoparticles ( EPI-PBCA-MNPs) for the purpose of offering a new dosage form of high-performance for targeted therapy of hepatoma. Methods Nanosized Fe3 O4 magnetic fluids with the mean particle diameter of (15. 2 ±4. 6) nm were prepared by chemical coprecipitation method. Subsequently, EPI-PBCA-MNPs was prepared by a reversed-phase micro-emulsion polymerization method, of which reactive condition was pH = 2. 0 and agitating velocity = 2000 r/min, and was correlatively characterized. Results EPI-PBCA-MNPs were uniformly and stably distributed in the colloid solution with the mean particle diameter of (152.0 ±28. 5) nm. The mean envelopment rate, drug-loading, saturated magnetization intensity is (81. 30 ±15. 20) % ,(14. 65 ± 2.05) % ,0. 35 KA/m, respectively. Conclusion In this experiment, EPI-PBCA-MNPs is uniformly distributed with satisfactory particle diameter,of which main indexes meet the demand of targeted therapy for hepatoma, offering a new dosage form with applicable potential for anticancer drugs exploration.