CAJ | 학술논문

目的探讨高压氧干预下急性脑梗死(ACI)患者CD11和CD54变化及其对预后影响.方法将ACI患者64例分为对照组33例和高压氧治疗组(高压氧组)31例.对照组行常规治疗,高压氧组行常规治疗并高压氧治疗.2组患者均在发病≤72 h及发病第7,10,12和20天晨抽取外周静脉血测定CD11a、CD11c和CD 54,并在相同发病时间采用神经功能缺损程度评分(NDS).另外选取健康者25例作为正常对照,仅抽取周围静脉血测定CD11a、CD11 c和CD54.结果高压氧组和对照组在发病≤72 h时CD11a、CD11c和CD54表达达到高峰,2组之间各指标差异不显著,第7天都开始呈现下降趋势.高压氧组CD11a、CD11 c高峰持续时间7 d,对照组持续10 d;CD54高峰持续时间高压氧组为10 d,对照组为12 d.经相关和线性回归分析发现,发病第20天时NDS的水平(近期疗效)和发病半年、1年时NDS的水平(远期疗效)分别有97.3%、96.7%及96.6%可用发病前CD11a和/或CD11c和/或CD54的水平以及其他相关因素解释.结论高压氧治疗可缩短ACI患者CD11a、CD11 c和CD54高峰维持时间.高压氧可干预细胞黏附分子的变化过程,缩短异常时限,减少它们的表达,对ACI患者有保护作用.同时治疗前CD11a、CD11c和CD54的表达可预测病情的轻重,影响近远期疗效,预测预后.
목적 탐토고압양간예하급성뇌경사(ACI)환자CD11화CD54변화급기대예후영향.방법 장ACI환자64례분위대조조33례화고압양치료조(고압양조)31례.대조조행상규치료,고압양조행상규치료병고압양치료.2조환자균재발병≤72 h급발병제7,10,12화20천신추취외주정맥혈측정CD11a、CD11c화CD 54,병재상동발병시간채용신경공능결손정도평분(NDS).령외선취건강자25례작위정상대조,부추취주위정맥혈측정CD11a、CD11 c화CD54.결과 고압양조화대조조재발병≤72 h시CD11a、CD11c화CD54표체체도고봉,2조지간각지표차이불현저,제7천도개시정현하강추세.고압양조CD11a、CD11 c고봉지속시간7 d,대조조지속10 d;CD54고봉지속시간고압양조위10 d,대조조위12 d.경상관화선성회귀분석발현,발병제20천시NDS적수평(근기료효)화발병반년、1년시NDS적수평(원기료효)분별유97.3%、96.7%급96.6%가용발병전CD11a화/혹CD11c화/혹CD54적수평이급기타상관인소해석.결론 고압양치료가축단ACI환자CD11a、CD11 c화CD54고봉유지시간.고압양가간예세포점부분자적변화과정,축단이상시한,감소타문적표체,대ACI환자유보호작용.동시치료전CD11a、CD11c화CD54적표체가예측병정적경중,영향근원기료효,예측예후.
Objective To observe the changes of CD11 a, CD11c and CD54 and its' influence on prognosis after the intervention of hyperbaric oxygen(HBO) in patients with acute cerebral infarction (ACI).Methods Sixty-four ACI patients were divided into control group( C group) and HBO therapy group( HBOT group).C group (33 cases) received routine treatment only, HBOT group ( 31 cases) received routine treatment and hyperbaric oxygen therapy.CD 11 a, CD11 c and CD54 were measured in both groups at ≤72h, the 7th d, 10th d, 12th d, 20th d after ACI, and neural functional damage scores(NDS) were evaluated at the same time.CD11a, CDllc and CD54 were also measured in normal control group (25 cases).Results Plasma levels of CD11a, CD11c and CD54 rose significantly both in HBOT group and C group and peaked at≤72 h after ACI, there was no significant difference between two groups (P > 0.05), then declined at the 7th d.Levels of CD11 a, and CD11c maintained at the peak for 7 d in H BOT group and for 10 d in C group.CD54 peak remained for 10 d in HBOT group, and for 12 d in C group.A correlation analysis and linear regression analysis showed that the NDS levels at 20th d (short-term curative effect), 6 months and 12 months (long-term outcome) could be explained by 97.3 % , 96.7% and 96.6% , respectively by the admission levels of CD11 a and/or CD11 c and/or CD54 and other related factors.Conclusion After hyperbaric oxygen therapy peak level duration of CD11a, CD11c and CD54 could be shortened.Hyperbaric oxygen could influence intercellular adhesion molecule changing process, reduce leukocytes adhesion, decrease expressions of CD11a CD11c and CD54, and protect ACI patients.Before treatment, expression of CD11a, CD11c and CD54 may predict the severity, short or long-term outcome and prognosis of ACI patients.