中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
16期
18-20
,共3页
高血压%内皮%血管%C反应蛋白质%胞间黏附分子1
高血壓%內皮%血管%C反應蛋白質%胞間黏附分子1
고혈압%내피%혈관%C반응단백질%포간점부분자1
Hypertension%Endothelium,vascular%C-reactive protein%Intercellular adhesion molecule-1
目的 探讨原发性高血压患者内皮舒张因子[降钙素基因相关肽(CGRP)和前列环素(PGI2)]、内皮收缩因子[血栓烷B2(TXB2)和内皮素(ET)-1]与高敏C反应蛋白(ha-CRP)、可溶性细胞间黏附分子(sICAM)-1的关系.方法 选取未经治疗的原发性高血压患者42例作为高血压组,对照组由40例同期健康体检者组成.采用放免法测定CGRP、6-酮-前列腺素F1α(6-keto-PGF1α)、ET-1及TXB2水平;ELISA法测定sICAM-I水平;激光散射比浊法测定hs-CRP水平.结果 高血压组ET-1、TXB2、ha-CRP、sICAM-1水平[分别为(102.23±17.60)ng/L、(102.25±24.61)ng/L、(14.58±2.16)mg/L、(224.89±49.28)μg/L]显著高于对照组[分别为(50.81±6.54)ng/L、(76.11.±20.23)ng/L、(2.33±1.21)mg/L、(112.51±22.47)μg/L],高血压组CGRP、6-keto-PGF1α水平[分别为(28.95±9.68)、(54.26±18.96)ng/L]显著低于对照组[分别为(63.12±16.74)、(89.54±21.48)ng/L],差异均有统计学意义(P<0.01);高血压组ET-1、TXB2、ha-CRP、sICAM-1水平随着血压分级升高而升高,CGRP、6-keto-PGF1α水平随着血压分级升高而降低,组间比较差异有统计学意义(P<0.05或<0.01);高血压组hs-CRP、sICAM-1水平与ET-1及TXB2水平呈正相关,与CGRP、6-keto-PGF1α水平呈负相关.结论 血浆ET-1、TXB2和血清ha-CRP及sICAM-1水平变化与血压升高有紧密联系,且内皮功能与炎性因子存在相关性,提示它们参与了高血压的发生和发展.
目的 探討原髮性高血壓患者內皮舒張因子[降鈣素基因相關肽(CGRP)和前列環素(PGI2)]、內皮收縮因子[血栓烷B2(TXB2)和內皮素(ET)-1]與高敏C反應蛋白(ha-CRP)、可溶性細胞間黏附分子(sICAM)-1的關繫.方法 選取未經治療的原髮性高血壓患者42例作為高血壓組,對照組由40例同期健康體檢者組成.採用放免法測定CGRP、6-酮-前列腺素F1α(6-keto-PGF1α)、ET-1及TXB2水平;ELISA法測定sICAM-I水平;激光散射比濁法測定hs-CRP水平.結果 高血壓組ET-1、TXB2、ha-CRP、sICAM-1水平[分彆為(102.23±17.60)ng/L、(102.25±24.61)ng/L、(14.58±2.16)mg/L、(224.89±49.28)μg/L]顯著高于對照組[分彆為(50.81±6.54)ng/L、(76.11.±20.23)ng/L、(2.33±1.21)mg/L、(112.51±22.47)μg/L],高血壓組CGRP、6-keto-PGF1α水平[分彆為(28.95±9.68)、(54.26±18.96)ng/L]顯著低于對照組[分彆為(63.12±16.74)、(89.54±21.48)ng/L],差異均有統計學意義(P<0.01);高血壓組ET-1、TXB2、ha-CRP、sICAM-1水平隨著血壓分級升高而升高,CGRP、6-keto-PGF1α水平隨著血壓分級升高而降低,組間比較差異有統計學意義(P<0.05或<0.01);高血壓組hs-CRP、sICAM-1水平與ET-1及TXB2水平呈正相關,與CGRP、6-keto-PGF1α水平呈負相關.結論 血漿ET-1、TXB2和血清ha-CRP及sICAM-1水平變化與血壓升高有緊密聯繫,且內皮功能與炎性因子存在相關性,提示它們參與瞭高血壓的髮生和髮展.
목적 탐토원발성고혈압환자내피서장인자[강개소기인상관태(CGRP)화전렬배소(PGI2)]、내피수축인자[혈전완B2(TXB2)화내피소(ET)-1]여고민C반응단백(ha-CRP)、가용성세포간점부분자(sICAM)-1적관계.방법 선취미경치료적원발성고혈압환자42례작위고혈압조,대조조유40례동기건강체검자조성.채용방면법측정CGRP、6-동-전렬선소F1α(6-keto-PGF1α)、ET-1급TXB2수평;ELISA법측정sICAM-I수평;격광산사비탁법측정hs-CRP수평.결과 고혈압조ET-1、TXB2、ha-CRP、sICAM-1수평[분별위(102.23±17.60)ng/L、(102.25±24.61)ng/L、(14.58±2.16)mg/L、(224.89±49.28)μg/L]현저고우대조조[분별위(50.81±6.54)ng/L、(76.11.±20.23)ng/L、(2.33±1.21)mg/L、(112.51±22.47)μg/L],고혈압조CGRP、6-keto-PGF1α수평[분별위(28.95±9.68)、(54.26±18.96)ng/L]현저저우대조조[분별위(63.12±16.74)、(89.54±21.48)ng/L],차이균유통계학의의(P<0.01);고혈압조ET-1、TXB2、ha-CRP、sICAM-1수평수착혈압분급승고이승고,CGRP、6-keto-PGF1α수평수착혈압분급승고이강저,조간비교차이유통계학의의(P<0.05혹<0.01);고혈압조hs-CRP、sICAM-1수평여ET-1급TXB2수평정정상관,여CGRP、6-keto-PGF1α수평정부상관.결론 혈장ET-1、TXB2화혈청ha-CRP급sICAM-1수평변화여혈압승고유긴밀련계,차내피공능여염성인자존재상관성,제시타문삼여료고혈압적발생화발전.
Objective To study the relationship between endothelial diastolic factor[calcitoningene-related peptide(CGRP),prostaglandin I2(PGI2)],endothelial contract factor[endothelin(ET)-1,thromboxane B2(TXB2)],the serum high-sensitivity C reactive protein(ha-CRP)and soluble intercellular adhesion molecule(sICAM)-1 level in patients with essential hypertension(EH).Methods Forty-two EH patienm(EH group)received no medication were randomly divided into 3 subgroups(class 1,class 2,class 3),and 40 healthy volunteers were enrolled as control group.The levels of CGRP,6-keto-PGF1α,ET-1,TXB2 were determined by the method of radioimmunity,and the serum level of sICAM-1 Was detected by ELISA while the level of hs-CRP was detected by the method of Laser nephelometry.Results The levels of ET-1,TXB2,ha-CRP,sICAM-1 were higher,whereas the levels of CGRP,6-keto-PGF1α were lower in EH group[(102.23±17.60)ng/L,(102.25±24.61)ng/L,(14.58±2.16)mg/L,(224.89±49.28)μg/L,(28.95±9.68)ng/L,(54.26±18.96)ng/L,respectively]than those in control group[(50.81±6.54)ng/L,(76.11 ±20.23)ng/L,(2.33±1.21)mg/L,(112.51±22.47)μg/L,(63.12±16.74)ng/L,(89.54±21.4s)ng/L,respectively](P<0.01).the levels of ET-1,TXB2,hs-CBP,sICAM-1 increased,whiled the CGRP,6-keto-PGF1α levels decreased in order in class 1,class 2 and class 3,and there were statistical differences between any two of the classes(P<0.05 or<0.01).The levels of hs-CRP and sICAM-1 were positively correlated with ET-1, TXB2,but negatively correlated with CGRP,6-keto-PGF1α in EH group.Conclusions The changes of ET-1,TXB2,hs-CBP,sICAM-1 have a close relation with the levels of blood pressure in EH patients,and there are correlations between vascular endothelial function and inflammation factor.These suggest that they may be involved in the genesis and development of hypertension.
