CAJ | 학술논문

人类Toll样受体(TLR)是近年来发现的一类新的细胞表面信号传导跨膜受体,是人体固有免疫和适应性免疫的桥梁.TLR4组织分布较广泛,激活后通过TLR4-NF-κB信号途径促进细胞因子合成、激活T细胞、调节Th1/Th2免疫反应的平衡,从而调节机体的免疫状态.进一步研究TLR4的信号转导途径及其在疾病发展过程中的表达情况,可以为临床预防和治疗疾病提供新的思路和方法.
인류Toll양수체(TLR)시근년래발현적일류신적세포표면신호전도과막수체,시인체고유면역화괄응성면역적교량.TLR4조직분포교엄범,격활후통과TLR4-NF-κB신호도경촉진세포인자합성、격활T세포、조절Th1/Th2면역반응적평형,종이조절궤체적면역상태.진일보연구TLR4적신호전도도경급기재질병발전과정중적표체정황,가이위림상예방화치료질병제공신적사로화방법.
Toll-like Receptors(TLRs)is a kind of transmembrane receptor which transduct signals on cell surface.It is the bridge of inherent immunity and adaptive immunity.TLR4 exists in many kinds of tissues.When TLR4 is activated.signals are transmited through TLR4-NF-κB pathway to promote the synthesis of cytokines which in turn activate T cells and regulate the balance of Th1/Th2 reaction.Further study on TLR4 signaling pathway and its immune function may provide new approach for the prevention and treatment of diseases.