CAJ | 학술논문

目的探讨Wells综合征的临床及病理特征和治疗情况.方法回顾性分析7例Wells综合征的临床及病理资料.结果 7例患者中,皮损分别位于双下肢(4例)、背部(1例)、面部和躯干(1例)及臀部(1例)；临床表现为蜂窝织炎样(3例)、荨麻疹样(1例)、环状红色斑块(1例)和丘疹结节(2例).组织病理学检查均示真皮内大量嗜酸粒细胞浸润,伴有“火焰征”,3例同时伴有血管炎改变.7例患者均无明显的发病诱因.3例给予小剂量糖皮质激素和雷公藤多苷口服,皮损基本消退.结论 Wells综合征具有多种临床表现,组织学上具有特征性,系统性糖皮质激素和雷公藤多苷治疗有效.
목적 탐토Wells종합정적림상급병리특정화치료정황.방법 회고성분석7례Wells종합정적림상급병리자료.결과 7례환자중,피손분별위우쌍하지(4례)、배부(1례)、면부화구간(1례)급둔부(1례)；림상표현위봉와직염양(3례)、담마진양(1례)、배상홍색반괴(1례)화구진결절(2례).조직병이학검사균시진피내대량기산립세포침윤,반유“화염정”,3례동시반유혈관염개변.7례환자균무명현적발병유인.3례급여소제량당피질격소화뢰공등다감구복,피손기본소퇴.결론 Wells종합정구유다충림상표현,조직학상구유특정성,계통성당피질격소화뢰공등다감치료유효.
Objective To assess the clinical and histopathological features as well as treatment of Wells syndrome.Methods The clinical and pathological findings from 7 patients with Wells syndrome were retrospectively reviewed.Results Lesions were located on both lower extremities in 4 patients,on the back in 1 patient,on the face and trunk in 1 patient,and on the buttocks in 1 patient.Clinical manifestations included cellulitis (n =3),urticaria (n =1 ),annular plaques (n =1 ) and papulonodules (n =2).Histopathological examination of skin biopsies showed an infiltrate of numerous eosinophils with occasional flame figures in the dermis of all the patients.Leucocytoclastic vasculitis was found in 3 cases.No triggering factors were found in any of the 7 cases.The lesions nearly subsided in 3 patients after 2-week treatment with oral small-dosage prednisone and tripterygium glycosides.Conclusions Wells syndrome shows a wide diversity of clinical manifestations with distinct histological features.Systemic glucocorticoids and tripterygium glycosides are effective for the control of this condition.