CAJ | 학술논문

目的探讨C-erbB-2在甲状腺良恶性疾病中的表达及其临床意义.方法应用免疫组织化学SP法检测66例甲状腺手术切除标本的C-erbB-2.结果甲状腺良性疾病中C-erbB02的阳性率为13.95%(6/43),甲状腺癌中C-erbB-2的阳性率为39.13%(9/23),两者差异有统计学意义(P<0.025).在甲状腺良恶性疾病中,C-erbB-2的阳性表达均与患者性别、年龄、肿瘤部位无关(P>0.05),C-erbB-2的阳性表达与甲状腺癌肿瘤大小显著相关(P<0.05).C-erbB-2与甲状腺癌的淋巴结转移无显著相关性(P>0.05).结论 C-erbB-2与甲状腺癌的发生及转化方面有一定关系.
목적 탐토C-erbB-2재갑상선량악성질병중적표체급기림상의의.방법 응용면역조직화학SP법검측66례갑상선수술절제표본적C-erbB-2.결과 갑상선량성질병중C-erbB02적양성솔위13.95%(6/43),갑상선암중C-erbB-2적양성솔위39.13%(9/23),량자차이유통계학의의(P<0.025).재갑상선량악성질병중,C-erbB-2적양성표체균여환자성별、년령、종류부위무관(P>0.05),C-erbB-2적양성표체여갑상선암종류대소현저상관(P<0.05).C-erbB-2여갑상선암적림파결전이무현저상관성(P>0.05).결론 C-erbB-2여갑상선암적발생급전화방면유일정관계.
Objective To study the clinical significance of C-erbB-2 expression in benign and malignant thyroid lesions. Methods The expressions of C-erbB-2 were detected by immunohistochemistry assays in 66 ca-ses of thyroid lesions. Results The positive rates of C-erbB-2 expression was 13.95% (6/43) in benign thyroid diseases, 39.13% (9/23) in malignant thyroid diseases. There was significant difference between the expression of C-erbB-2 in malignant thyroid lesions and that in benign lesions(P<0.025). The analysis with corresponding clinical prognostic factors showed that the positive expression of C-erbB-2 in benign and malignant thyroid lesions had no correlation with sex, age, lymph nodes metastase and node position(P >0. 05). Expressions of C-erbB-2 had a significant positive correlation with tumor diameter (P < 0. 05). Conclusions C-erbB-2 expression is cor-related with the carcinogenesis and development of thyroid carcinoma.