CAJ | 학술논문

目的探讨成人接种卡介苗对慢性支气管炎的治疗与预防作用.方法以分层整群随机抽样确定科研点的县、乡,再以乡的村为单位随机分为研究组和对照组,对其中20～55岁非肿瘤、结核病现症患者的自愿村民按性别、年龄分别配对,给研究组进行卡介苗接种,每6个月1次连续3次;依靠县、乡、村三级防疫网络,对慢性支气管炎患者的急性发作(复发)和新发生的慢性支气管炎患者进行监测.结果抽取的4个乡,计83个村,共有慢性支气管炎患者2 047例,患病率为1.89%(2 047/108 189).纳入监测的20～55岁村民共24 830人,有慢性支气管炎患者161例,患病率为0.65%.其中研究组84例,对照组77例.在1997年12月至2009年12月监测期间,研究组死亡5例.尚存的79例慢性支气管炎患者中急性发作39例,共计275次(人次);对照组死亡7例,尚存的70例慢性支气管炎患者急性发作65例,共计922次.在患者复发率及复发的次数(人次)方面,研究组与对照组比较差异均有统计学意义(χ~2=33.300,P<0.01;U=351.000,P<0.01).研究组原非慢性支气管炎患者12 331人中死亡451人,新发慢性支气管炎76例,慢性支气管炎发生、复发共计869次;对照组原非慢性支气管炎患者12 338人中死亡597人,新发慢性支气管炎127例,慢性支气管炎发生、复发共计2 349次.在慢性支气管炎发病率及发生、复发的次数(人次)方面,研究组与对照组间的差异亦均有统计学意义(χ~2=13.537,P<0.01;U=1496.000,P<0.01).结论研究结果显示成人接种卡介苗对慢性支气管炎的发生有一定预防作用,对慢性支气管炎患者减少复发有一定治疗作用.
목적 탐토성인접충잡개묘대만성지기관염적치료여예방작용.방법이분층정군수궤추양학정과연점적현、향,재이향적촌위단위수궤분위연구조화대조조,대기중20～55세비종류、결핵병현증환자적자원촌민안성별、년령분별배대,급연구조진행잡개묘접충,매6개월1차련속3차;의고현、향、촌삼급방역망락,대만성지기관염환자적급성발작(복발)화신발생적만성지기관염환자진행감측.결과 추취적4개향,계83개촌,공유만성지기관염환자2 047례,환병솔위1.89%(2 047/108 189).납입감측적20～55세촌민공24 830인,유만성지기관염환자161례,환병솔위0.65%.기중연구조84례,대조조77례.재1997년12월지2009년12월감측기간,연구조사망5례.상존적79례만성지기관염환자중급성발작39례,공계275차(인차);대조조사망7례,상존적70례만성지기관염환자급성발작65례,공계922차.재환자복발솔급복발적차수(인차)방면,연구조여대조조비교차이균유통계학의의(χ~2=33.300,P<0.01;U=351.000,P<0.01).연구조원비만성지기관염환자12 331인중사망451인,신발만성지기관염76례,만성지기관염발생、복발공계869차;대조조원비만성지기관염환자12 338인중사망597인,신발만성지기관염127례,만성지기관염발생、복발공계2 349차.재만성지기관염발병솔급발생、복발적차수(인차)방면,연구조여대조조간적차이역균유통계학의의(χ~2=13.537,P<0.01;U=1496.000,P<0.01).결론 연구결과현시성인접충잡개묘대만성지기관염적발생유일정예방작용,대만성지기관염환자감소복발유일정치료작용.
Objective To discuss the prevention and treatment of bacille calmette-guerin(BCG) vaccination for adults with chronic bronchitis. Methods The county and town were determined as sampling by stratified-cluster-random method. Then the villages in the town were used as units and divided into study group and control group randomly. The voluntary villagers who had no tumor but tuberculosis from 20 to 55 years old matched by gender and age. BCG was vaccinated to study group every six months for three times. The recrudescent and new patients with chronic bronchitis were monitored by epidemic prevention net of county,town and village. Results There were 2 047 cases of chronic bronchitis in the four towns which had 83 villages,and the sickness rate was 1.89% (2 047/108 189). The villagers from 20 to 55 years old who were brought into the monitor were 24 830 cases,among which there were 161 cases of chronic bronchitis,and the sickness rate was 0.65%. There were 84 cases in study group and 77 cases in control group. Within the monitoring time from December 1997 to December 2009, in study group, five cases died,and among the rest 79 cases,39 cases suffered from recrudescence of chronic bronchitis, 275 times in total. In control group, seven cases died, and among the rest 70 cases, 65 cases suffered form recrudescence of chronic bronchitis, 922 times in total. On the relapse rate and relapse times, there was statistical difference between study group and control group(χ~2 = 33.300, P<0.01 ; U = 351.000, P 0.01). In study group,451 people died in 12 331 people who were original non-chronic bronchitis patients, there were 76 cases newly issued chronic bronchitis, and the times of occurrence and recrudescence of chronic bronchitis were 869 in total. In control group,597 people died in 12 338 people who were original non-chronic bronchitis patients, there were 127 cases newly issued chronic bronchitis, and the times of occurrence and recrudescence of chronic bronchitis were 2 349 in total. On the incidence and times of occurrence and recrudescence of chronic bronchitis, there was statistical difference between study group and control group(χ~2=13.537, P<0.01 ; U = 1496.000, P<0.01). Conclusions The results show that BCG vaccination for the adults may have the preventive effect for the chronic bronchitis and treatment (control) effect for the recrudescence of chronic bronchitis.