CAJ | 학술논문

将60只昆明系小白鼠随机分为5个剂量的小花棘豆试验组（A、B、C、D、E组小花棘豆剂量分别为日粮的60％、40％、20％、10％、5％）和1个对照组（F组）．进行为期60d的小花棘豆毒性试验。结果表明，在小白鼠日粮中添加20％小花棘豆，在60d试验期内未出现小白鼠死亡；添加40％小花棘豆，第57天出现死亡；添加60％小花棘豆，第45天出现死亡。随着小花棘豆在日粮中含量的增加。小白鼠的增重幅度明显减慢，其中A、B、C组小白鼠的试验终体重与对照组差异极显著（P〈0．01），D组与对照组差异显著（P〈0．05），E组与对照组无显著性差异。各剂量组小白鼠与对照组小白鼠相比．心脏、脾脏、脑和肺脏的脏器系数变化不大；肝脏系数和肾脏系数随着小花棘豆剂量的增加而增大，日粮中小花棘豆含量越高，小白鼠肝、肾肿大越严重，A、B、C组与对照组相比较差异极显著（P〈0．01），表明日粮中小花棘豆剂量达到20％时．就会对肝、肾脏造成损伤。
장60지곤명계소백서수궤분위5개제량적소화극두시험조（A、B、C、D、E조소화극두제량분별위일량적60％、40％、20％、10％、5％）화1개대조조（F조）．진행위기60d적소화극두독성시험。결과표명，재소백서일량중첨가20％소화극두，재60d시험기내미출현소백서사망；첨가40％소화극두，제57천출현사망；첨가60％소화극두，제45천출현사망。수착소화극두재일량중함량적증가。소백서적증중폭도명현감만，기중A、B、C조소백서적시험종체중여대조조차이겁현저（P〈0．01），D조여대조조차이현저（P〈0．05），E조여대조조무현저성차이。각제량조소백서여대조조소백서상비．심장、비장、뇌화폐장적장기계수변화불대；간장계수화신장계수수착소화극두제량적증가이증대，일량중소화극두함량월고，소백서간、신종대월엄중，A、B、C조여대조조상비교차이겁현저（P〈0．01），표명일량중소화극두제량체도20％시．취회대간、신장조성손상。
60 Kunming mice were randomly divided into 5 test groups （A, B, C, D, E）with different doses of Oxytropis glabra DC （60%, 40% ,20%, 10% ,5% ）and a control group. The toxicity test of O. glabra was carried out for 60 days. The results showed that mice that were fed with the diet with adding 20% O. globra all survived within 60 days. And mice in the group of adding 40% O. glabra began to die after 57 days. And mice in the group of adding 60% O. glabra began to die after 45 days. The weight gain rate of mice obviously decreased with the increasing of O. glabra in the diet. The final weight of mice in A, B, C test groups was extremely significantly different with control group （P〈0.01 ）. And the weight gain of mice in D test group was significantly different with control group （P〈0.05） and that in E group had no significant difference with control group. Compared with control group ,the viscera coefficients （heart, spleen, brain and lung） of mice in different dose groups changed little. The liver coefficient and kidney coefficient increased with the increasing of the dose of O. glabra. The higher the content of O. glabra in the diet was, the more seriously mice＇s liver and kidney were swollen. And the differences of mice＇s liver and kidney between A, B, C groups and control group was extremely significant （P〈0.01）, which O. gla/bra would caused the injury to the liver and kidney when the dose of O. glabra reached 20%.