纯粹数学与应用数学
純粹數學與應用數學
순수수학여응용수학
PURE AND APPLIED MATHEMATICS
2011年
4期
515-522
,共8页
童姗姗%窦霁虹%贾玲%王佳颖
童姍姍%竇霽虹%賈玲%王佳穎
동산산%두제홍%가령%왕가영
最大值最小值原理%t分布检验%相关性分析%0—1矩阵%优化模型
最大值最小值原理%t分佈檢驗%相關性分析%0—1矩陣%優化模型
최대치최소치원리%t분포검험%상관성분석%0—1구진%우화모형
maximum and minimum principle%t-distribution test%correlation analysis%0-1 matrix%optimization model
所建立的模型及所得的结论有利于利用数据库中已有的基因信息快速筛选出潜在的癌症相关基因，模型一和模型二以基因表达水平限值和差异显著性水平为分类要素，将基因分为两类．模型三利用逐步优化思想建立优化模型，确定出六组基因标签．模型四利用小波分析法去噪及相关性检验法，重新确定基因标签，包含8种特征基因，对癌症样本的检测率降低了，说明数据中的噪声能对确定基因标签产生有利的影响．
所建立的模型及所得的結論有利于利用數據庫中已有的基因信息快速篩選齣潛在的癌癥相關基因，模型一和模型二以基因錶達水平限值和差異顯著性水平為分類要素，將基因分為兩類．模型三利用逐步優化思想建立優化模型，確定齣六組基因標籤．模型四利用小波分析法去譟及相關性檢驗法，重新確定基因標籤，包含8種特徵基因，對癌癥樣本的檢測率降低瞭，說明數據中的譟聲能對確定基因標籤產生有利的影響．
소건립적모형급소득적결론유리우이용수거고중이유적기인신식쾌속사선출잠재적암증상관기인，모형일화모형이이기인표체수평한치화차이현저성수평위분류요소，장기인분위량류．모형삼이용축보우화사상건립우화모형，학정출륙조기인표첨．모형사이용소파분석법거조급상관성검험법，중신학정기인표첨，포함8충특정기인，대암증양본적검측솔강저료，설명수거중적조성능대학정기인표첨산생유리적영향．
The models and conclusions in this paper which facilitate the usage of the existing gene infomation in the database to screen out the potential tumor-related genes rapidly are studied. The limit value of gene expression and the level of significance of difference are considered as the classification factors in modelⅠ and model Ⅱ, and genes can be divided into two categories. By using zhe stepwise optimizing idea, optimization model and six groups of optimal gene tags are obtained in model Ⅲ. By using the wavelet analysis and correlation test, the gene tags are re-determined in modle Ⅳ, including eight kinds of characteristic genes. By the decrease of the detection rate of cancer samples, that noise in the data produces beneficial effects for determining the gene tags is indicated.
