CAJ | 학술논문

目的　探讨Fas和Bcl-2在膀胱移行细胞癌的表达及其与膀胱癌生物学行为的关系。方法　应用免疫组化SABC法检测42例膀胱移行细胞癌标本中Fas和Bcl-2的表达情况，并与膀胱癌的病理分级、临床分期及随访结果相比较。结果　31例（73.8%）Fas表达阳性，23例（56.1%）Bcl-2表达阳性，低分化和晚期膀胱移行细胞癌中二者表达均增加。结论　Fas和Bcl-2表达可以作为监测膀胱移行细胞癌恶性程度、预测复发的重要指标。在低分化和晚期膀胱移行细胞癌中，Fas所介导的细胞凋亡可能被Bcl-2的过度表达所抑制。
목적　탐토Fas화Bcl-2재방광이행세포암적표체급기여방광암생물학행위적관계。방법　응용면역조화SABC법검측42례방광이행세포암표본중Fas화Bcl-2적표체정황，병여방광암적병리분급、림상분기급수방결과상비교。결과　31례（73.8%）Fas표체양성，23례（56.1%）Bcl-2표체양성，저분화화만기방광이행세포암중이자표체균증가。결론　Fas화Bcl-2표체가이작위감측방광이행세포암악성정도、예측복발적중요지표。재저분화화만기방광이행세포암중，Fas소개도적세포조망가능피Bcl-2적과도표체소억제。
Objective　To investigate Fas and Bcl-2 gene expression and to evaluate their significance on the biological behavior of the tumor.Methods　Fas and Bcl-2 gene expression were detected in 42 specimens by immunohistochemistry.Results　31(73.8%) cases were positive in Fas expression, while 23 (56.1%) cases were positive in Bcl-2 expression. The expression of Fas and Bcl-2 increased in bladder neoplasms of low differentiation and late stages.Conclusions　The expression of Fas and Bcl-2 might have a practical significance in assessing the malignancy and recurrence. Overexpression of Bcl-2 in bladder transitional cell carcinoma resulted in a partial inhibition of Fas-induced cell death.