世界胃肠病学杂志（英文版）
世界胃腸病學雜誌（英文版）
세계위장병학잡지（영문판）
WORLD JOURNAL OF GASTROENTEROLOGY
2007年
28期
3783-3791
,共9页
Colorectal cancer%Neoplastic processes%Adenoma-carcinoma sequence%Serrated adenoma%Adenomas%Hyperplastic polyps,Microsatellite instability%CpG Island methylator phenotype
This review explores the chief genetic and epigenetic events that promote pathological progression in colorectal carcinogenesis. This article discusses the molecular and pathological basis for classifying colorectal neoplasia into suppressor, mutator and methylator pathways.These differing mechanisms of genomic instability are associated with specific cancer characteristics, and may provide the opportunity for more effective prevention and surveillance strategies in the future. This is the first review in a series of five topics outlining important and developing aspects of colorectal cancer.
