CAJ | 학술논문

在本研究的第Ⅱ部分,已经报告了和芍药甘草汤(SGT)合用的抗菌剂组合AMPC-MET(amoxicillin,AMPC,and metronidazole,MET)显著降低了SGT中甘草酸(glycyrrhizin,GL)的生物利用度,原因在于其降低了肠内细菌将GL代谢成甘草次酸(18β-glycyrrhetic acid,GA)的活性.在本文,即本研究的第Ⅲ部分,笔者对AMPC-MET的降低作用的持续时间以及可减少这种作用的适当的合并给药方案进行了探讨.实验结果显示,肠内细菌的GL代谢活性被AMPGMET降低后,需要12 d才可恢复到正常水平,而AMPC-MET给药1 d后开始进行SGT给药,被AMPC-MET显著降低了的肠内细菌的GL代谢活性以及GA血药浓度4 d后得以快速恢复到正常水平.本研究的结果表明,在抗菌剂和SGT的合并疗法中,为了减少抗菌剂对SGT中GL生物利用度的影响,可在抗菌剂给药1 d或2 d后对SGT进行连续投药.该给药方案也可应用于临床上.
재본연구적제Ⅱ부분,이경보고료화작약감초탕(SGT)합용적항균제조합AMPC-MET(amoxicillin,AMPC,and metronidazole,MET)현저강저료SGT중감초산(glycyrrhizin,GL)적생물이용도,원인재우기강저료장내세균장GL대사성감초차산(18β-glycyrrhetic acid,GA)적활성.재본문,즉본연구적제Ⅲ부분,필자대AMPC-MET적강저작용적지속시간이급가감소저충작용적괄당적합병급약방안진행료탐토.실험결과현시,장내세균적GL대사활성피AMPGMET강저후,수요12 d재가회복도정상수평,이AMPC-MET급약1 d후개시진행SGT급약,피AMPC-MET현저강저료적장내세균적GL대사활성이급GA혈약농도4 d후득이쾌속회복도정상수평.본연구적결과표명,재항균제화SGT적합병요법중,위료감소항균제대SGT중GL생물이용도적영향,가재항균제급약1 d혹2 d후대SGT진행련속투약.해급약방안야가응용우림상상.
In part Ⅱ, we reported that the co-administration of antibacterial drugs AMPC-MET (amoxicillin, AMPC,and metronidazole, MET) significantly decreased the bioavailability of glycyrrhizin (GL) fim Shaoyao-Gancao-Tang (SGT) ,due to their decreasing effects on the Gl-metabolizing activity of intestinal bacteria. In this part Ⅲ, the lasting time period of the influences of AMPC-MET on the GL-metabolizing activity and an appropriate medication regiment to minimize the influences were investigated. The results showed that the decreasing effects of AMPC-MET on the GL-metabolizing activity lasted for approx 12 days. However, repetitive administration of SGT starting 1 day after the treatment with AMPC-MET for 4 days significantly accelerated the recovery of the reduced plasma 18 β-glycyrrhetic acid(GA) concentration and the GL-etabolizing activity of rat feces. The present results suggest that it may be clinically useful to administer SGT repetitively starting 1 or 2 days after the antibiotic treatment during combination therapy with SGT and antibiotics to accelerate the recovery of the reduced bioavailability of GL in SGT.