CAJ | 학술논문

目的：探讨膀胱移行细胞癌增殖细胞核抗原(P CNA)的表达与肿瘤病理分级、临床分期、预后的关系。方法：采用免疫组化S-P法检测65例膀胱移行细胞癌和11例正常膀胱组织PCNA的表达。结果：PCNA在膀胱癌及正常膀胱组织的表达差异有显著性(P＜0.01) ；随着膀胱癌病理分级、临床分期升高，PCNA阳性表达上升，Ⅰ级、Ⅱ级与Ⅲ级比较，PCNA 的阳性表达差异均有显著性(P＜0.01)；T2～T4期PCNA的阳性表达显著高于Tis～T 1期(P＜0.005)；术后5年内无复发组PCNA的阳性表达显著低于术后5年内复发组( P＜0.005)。结论：PCNA可作为膀胱癌恶性程度及预后判断的指标之一，可指导临床综合治疗。
목적：탐토방광이행세포암증식세포핵항원(P CNA)적표체여종류병리분급、림상분기、예후적관계。방법：채용면역조화S-P법검측65례방광이행세포암화11례정상방광조직PCNA적표체。결과：PCNA재방광암급정상방광조직적표체차이유현저성(P＜0.01) ；수착방광암병리분급、림상분기승고，PCNA양성표체상승，Ⅰ급、Ⅱ급여Ⅲ급비교，PCNA 적양성표체차이균유현저성(P＜0.01)；T2～T4기PCNA적양성표체현저고우Tis～T 1기(P＜0.005)；술후5년내무복발조PCNA적양성표체현저저우술후5년내복발조( P＜0.005)。결론：PCNA가작위방광암악성정도급예후판단적지표지일，가지도림상종합치료。
Objective:To investigate the expression of P CNA in human bladder transitional cell carcinoma(TCC) and its relationship with the hi stological grades,clinical stages and prognosis of TCC.Methods:PCNA expression was detected by S-P immunohistochemistry me thod in 65 TCC cases and 11 normal bladder tissues.Results:The expression of PCNA between TCC group and normal tissue g roup was significantly different(P＜0.01).The poorer the differentiation of bladder cancer was related to the higher level of the PCNA positive expression. The c arcinoma of (Ⅰ,Ⅱ)grades,(Tis～T\-1) stages exhibited lower PCNA expression lev el as compared with Ⅲ grade,(T\-2～T\-4) stages respectively(P＜0.005).The expression of PCNA in recurrence group was significantly higher than that in no nrecurrence group(P＜0.005).Conclusions:PCNA could be used as a marker in the determination of t he malignancy,therapy and prognosis of TCC.