CAJ | 학술논문

目的　多普勒超声检测高血压病（CH）患者的肱动脉内皮细胞的功能。方法　采用超声显像法对44例EH患者和22例正常组肱动脉测定，静息状态下血管内径，血流速度，反应性充血时的内径及血流速度，和舌下含服0.3mg硝酸甘油后5min测血管内径和血流速度。结果　EH组反应性充血诱发的肱动脉内径变化百分率明显低于对照组（P<0.001），反应性充血时的肱动脉血流速度EH组也明显低于正常对照组（P<0.05）。服药后诱发血管扩张内径百分变化率EH组也低于对照组（P<0.05）。结论　 EH组血管内皮功能受损，硝酸甘油诱发的扩血管反应也有所下降。
목적 　다보륵초성검측고혈압병（CH）환자적굉동맥내피세포적공능。방법 　채용초성현상법대44례EH환자화22례정상조굉동맥측정，정식상태하혈관내경，혈류속도，반응성충혈시적내경급혈류속도，화설하함복0.3mg초산감유후5min측혈관내경화혈류속도。결과 　EH조반응성충혈유발적굉동맥내경변화백분솔명현저우대조조（P<0.001），반응성충혈시적굉동맥혈류속도EH조야명현저우정상대조조（P<0.05）。복약후유발혈관확장내경백분변화솔EH조야저우대조조（P<0.05）。결론　 EH조혈관내피공능수손，초산감유유발적확혈관반응야유소하강。
Objective 　To determine endothelial function in the brachial artery of patients with hypertension. Methods　 In 44 patients with essential hypertension (EH)，using the vascular ultrasonic technique，diameter and blood flow of the brachial artery at rest，during reactive hyperemia and after nitroglycerin administration were examined respectively. Results 　The percent change in brachial arterial diameter during reactive hyperemia and after nitroglycerin administration were significantly lower in patients with hypertension than control subjects (6±5%vs18±7%, P<0.001, 17±9%vs28±12%, P<0.05). Conclusion 　These finding suggest that vascular endothelial function was impaired and nitroglycerin - induced vasodilation was reduced in hypertensive patients.