CAJ | 학술논문

目的：评估复方卡尼汀治疗慢性病毒性肝炎的作用。方法：91例慢性病毒性肝炎病人分为2组。对照组30例(男性20例，女性10例，年龄41 a± s 17 a)，给予甘草酸单铵80 mL加入10%葡萄糖注射液500 mL中iv,gtt,qd，疗程30 d。治疗组61例(男性49例，女性12例，年龄40 a±13 a)，在甘草酸单铵治疗基础上，给予复方卡尼汀2支加入10%葡萄糖注射液500 mL中iv,gtt,qd，疗程30 d。结果：治疗组对改善病人乏力、纳差、降低ALT的总有效率分别为93%，100%，92%，均明显优于对照组75%，84%，70%(P<0.05)。对2组部分病人治疗6 mo时的随访表明治疗组的ALT复常率为83%，明显高于对照组54%(P<0.05)，无明显不良反应。结论：复方卡尼汀是一种有效的治疗慢性病毒性肝炎的药物。
목적：평고복방잡니정치료만성병독성간염적작용。방법：91례만성병독성간염병인분위2조。대조조30례(남성20례，녀성10례，년령41 a± s 17 a)，급여감초산단안80 mL가입10%포도당주사액500 mL중iv,gtt,qd，료정30 d。치료조61례(남성49례，녀성12례，년령40 a±13 a)，재감초산단안치료기출상，급여복방잡니정2지가입10%포도당주사액500 mL중iv,gtt,qd，료정30 d。결과：치료조대개선병인핍력、납차、강저ALT적총유효솔분별위93%，100%，92%，균명현우우대조조75%，84%，70%(P<0.05)。대2조부분병인치료6 mo시적수방표명치료조적ALT복상솔위83%，명현고우대조조54%(P<0.05)，무명현불량반응。결론：복방잡니정시일충유효적치료만성병독성간염적약물。
AIM: To observe the clinical effect of compound carnitine in treating chronic viral hepatitis.　METHODS: Ninety-one patients with chronic viral hepatitis were randomly divided into 2 groups. Control group of 30 patients (M 20,F 10; age 41 a± s 17 a) received compound glycynhizin 80 mL in 10% glucose injection 500 mL, iv, gtt, qd for 30 d. The treatment group of 61 patients(M 49,F 12; age 40 a±13 a) received compound carnitine 2 ampules. in 10% glucose injection 500 mL, iv, gtt, qd for 30 d, besides the compound glycyrrhizin therapy. 　RESULTS: The total response rate of improving the patients' fatigue, anorexia and normalization of ALT in the treatment group were 93%, 100% and 92% respectively, which was more excellent than that (75%, 84% and 70% respectively) in the control group (P<0.05). At the end of 6 mo treatment, the rate of the normalization of ALT in the treatment group was 83%, which was much higher than that (54%) in the control group (P<0.05), according to the statistics of the partial patients in both groups. No obvious adverse reaction was observed.CONCLUSION: Compound carnitine is an effective drug in treating chronic viral hepatitis.