CAJ | 학술논문

目的观察氨氯地平第三代二氢吡啶类钙拮抗剂对高血压病病人左心室向心性重构的影响。方法在6个月的随机单盲试验中，利用M型和多普勒超声心动图观察氨氯地平(5mg/d)对60例未经治疗的原发性高血压合并左心室向心性重构患者的左心室室壁厚度、左心室重量以及左心室重量指数的影响。结果氨氯地平可明显降低患者的收缩压以及舒张压(P＜0.01)，在降低血压的同时，氨氯地平可降低左心室室壁厚度(P＜0.01)、左心室重量(P＜0.05)和左心室重量指数(P＜0.01)。结论氨氯地平应用半年后，在平稳降压的同时可使向心性左室重构及左心室肥厚逆转。
목적 관찰안록지평제삼대이경필정류개길항제대고혈압병병인좌심실향심성중구적영향。방법 재6개월적수궤단맹시험중，이용M형화다보륵초성심동도관찰안록지평(5mg/d)대60례미경치료적원발성고혈압합병좌심실향심성중구환자적좌심실실벽후도、좌심실중량이급좌심실중량지수적영향。결과 안록지평가명현강저환자적수축압이급서장압(P＜0.01)，재강저혈압적동시，안록지평가강저좌심실실벽후도(P＜0.01)、좌심실중량(P＜0.05)화좌심실중량지수(P＜0.01)。결론 안록지평응용반년후，재평은강압적동시가사향심성좌실중구급좌심실비후역전。
Objective To observe the effect of the calcium antagonist-amlodipine on left ventricu-lar concentric remodeling in patients with primary hypertension. Methods In a 6-month randomised sin-gleblind trial, 60 cases of primary hypertension untreated previously received amlodipine(5mg, Qd).Mmode and Doppler echocardiography were used to observe the efficacy after 6 months. Results The blood pressure control was achieved with amlodipine(P＜0.00). Left ventricular mass was reduced significantly. Conclusion Amlodipine is effective in reducing left ventricular mass and left ventricular con-centric remodeling in previously untteated hypertension patients