标记免疫分析与临床
標記免疫分析與臨床
표기면역분석여림상
LABELED IMMUNOASSAYS AND CLINICAL MEDICINE
2001年
1期
15-17
,共3页
持续不卧床腹膜透析%甲状旁腺激素%骨钙素%维生素D
持續不臥床腹膜透析%甲狀徬腺激素%骨鈣素%維生素D
지속불와상복막투석%갑상방선격소%골개소%유생소D
了解腹膜透析患者的骨代谢状况。用IRMA、RRA和RIA对24例持续不卧床腹膜透析(CAPD)患者测定血清PTH(1-84)、25(OH)D3、1，25(OH)2D3、BGP以及血Ca和P的变化。结果表明：尿毒症患者PTH和BGP升高，CAPD可以使其降低；25(OH)D3和1，25(OH)2D3降低，CAPD对其无明显影响； PTH与25(OH)D3、1,25(OH)2D3呈负相关，P分别小于0.05和0.01；PTH与BGP呈正相关(P＜0.01），CAPD可使其相关性降低。提示PTH分泌亢进是骨代谢紊乱的主要因素之一，CAPD患者骨转化率降低。
瞭解腹膜透析患者的骨代謝狀況。用IRMA、RRA和RIA對24例持續不臥床腹膜透析(CAPD)患者測定血清PTH(1-84)、25(OH)D3、1，25(OH)2D3、BGP以及血Ca和P的變化。結果錶明：尿毒癥患者PTH和BGP升高，CAPD可以使其降低；25(OH)D3和1，25(OH)2D3降低，CAPD對其無明顯影響； PTH與25(OH)D3、1,25(OH)2D3呈負相關，P分彆小于0.05和0.01；PTH與BGP呈正相關(P＜0.01），CAPD可使其相關性降低。提示PTH分泌亢進是骨代謝紊亂的主要因素之一，CAPD患者骨轉化率降低。
료해복막투석환자적골대사상황。용IRMA、RRA화RIA대24례지속불와상복막투석(CAPD)환자측정혈청PTH(1-84)、25(OH)D3、1，25(OH)2D3、BGP이급혈Ca화P적변화。결과표명：뇨독증환자PTH화BGP승고，CAPD가이사기강저；25(OH)D3화1，25(OH)2D3강저，CAPD대기무명현영향； PTH여25(OH)D3、1,25(OH)2D3정부상관，P분별소우0.05화0.01；PTH여BGP정정상관(P＜0.01），CAPD가사기상관성강저。제시PTH분비항진시골대사문란적주요인소지일，CAPD환자골전화솔강저。
Bone metabolism in patients with chronic renal failure treated by continuous ambulatory peritoneal dialysis(CAPD) was evaluated.IRMA,RRA and RIA were used to detect PTH,25(OH)D3，1，25(OH)2D3，BGP，Ca and P levels in the blood of 24 CAPD patients.PTH and BGP were increased in uremic patients and decreased after CAPD.25(OH)D3 and 1,25(OH)2D3 were decreased in the patients,but their levels were not changed further after CAPD.PTH had negative correlation with 25(OH)D3(r=-0.379,P＜0.05) and 1,25(OH)2D3 (r=-0.451,P＜0.01）.PTH had positive correlation with BGP (r=0.501,P＜0.01）in CAPD patients,and the correlativity was decreased by CAPD.The results showed: PTH hypersecretion is a main factor inducing bone metabolism disturbance,and bone turnover rate is decreased in these patients by CAPD.
