CAJ | 학술논문

目的:探讨金属硫蛋白(MT)在食管癌和转移淋巴结组织中的表达及其与食管癌临床病理的联系。方法:应用免疫组织化学SABC法，以MT和细胞角蛋白4单克隆抗体标记10例正常食管粘膜、108例原发食管癌和188个区域淋巴结。结果:非典型增生的鳞状上皮MT阳性部位局限于基底和基底旁细胞，原发食管癌阳性率为54.6％(59/108)，淋巴结转移癌MT表达情况与原发癌基本相同。MT的表达与癌组织的分级、类型和角化型鳞癌的淋巴结转移有关(P<0.01,P<0.05)。结论:MT的超表达是食管粘膜上皮增生和角化型鳞癌转移的一种生物学标志，但其与淋巴结转移的联系则需进一步研究。
목적:탐토금속류단백(MT)재식관암화전이림파결조직중적표체급기여식관암림상병리적련계。방법:응용면역조직화학SABC법，이MT화세포각단백4단극륭항체표기10례정상식관점막、108례원발식관암화188개구역림파결。결과:비전형증생적린상상피MT양성부위국한우기저화기저방세포，원발식관암양성솔위54.6％(59/108)，림파결전이암MT표체정황여원발암기본상동。MT적표체여암조직적분급、류형화각화형린암적림파결전이유관(P<0.01,P<0.05)。결론:MT적초표체시식관점막상피증생화각화형린암전이적일충생물학표지，단기여림파결전이적련계칙수진일보연구。
Objective:To explore the correlations ofMetallothionein(MT)expression with clinicopathology in esophageal cancer and lymph node metastasis.Methods:Ten specimens normal esophageal mucosa,108 cases primary tumors and 188 regional lymph nodes were treated with immunohistochemical SABC method labelled by MT and cytokeratin 4 monoclonal antibody.Results：In dysplasia squamous epithelia positive staining with MT was confined to basal and parabasal cell.The positive staining was 54.6%(59/108) in primary esophageal cancer,and the same staining was seen in metastasis lymph node.The expression of MT was related to histological grades,patterns and lymph nodes metastasis of keratinized squamous cell carcinoma(P<0.01,P<0.05).Conclusion:MT over expression may be a biological marker in predicting epithelia proliferative and metastatic in keratinized squamous cell carcinoma of the esophagus.but further sdudies are needed to study the association of MT and lymph node metastasis.