合成化学
閤成化學
합성화학
CHINESE JOURNAL OF SYNTHETIC CHEMISTRY
2001年
1期
1-2
,共2页
N1-(2-呋喃烷基)-5-氟脲嘧啶%α-羟基(硫代)膦酸酯%氧化%加成反应
N1-(2-呋喃烷基)-5-氟脲嘧啶%α-羥基(硫代)膦痠酯%氧化%加成反應
N1-(2-부남완기)-5-불뇨밀정%α-간기(류대)련산지%양화%가성반응
N1- (2-furanidyl)- 5- fluorouracil%α- hydroxy ( thio ) phosphonate%oxidation%additonreaction
通过对N′-(2-呋喃烷基)-N3-(羟烷基)-5-氟脲嘧啶的氧化以及与O,O-二乙基硫代亚磷酸酯的加成反应合成了新型N1-(2-呋喃烷基)-5-氟脲嘧啶的α-羟基硫代膦酸酯衍生物,进一步以间氯过氧苯甲酸氧化得到相应的α-羟基膦酸酯衍生物.
通過對N′-(2-呋喃烷基)-N3-(羥烷基)-5-氟脲嘧啶的氧化以及與O,O-二乙基硫代亞燐痠酯的加成反應閤成瞭新型N1-(2-呋喃烷基)-5-氟脲嘧啶的α-羥基硫代膦痠酯衍生物,進一步以間氯過氧苯甲痠氧化得到相應的α-羥基膦痠酯衍生物.
통과대N′-(2-부남완기)-N3-(간완기)-5-불뇨밀정적양화이급여O,O-이을기류대아린산지적가성반응합성료신형N1-(2-부남완기)-5-불뇨밀정적α-간기류대련산지연생물,진일보이간록과양분갑산양화득도상응적α-간기련산지연생물.
Several N1-(2-furanidyl)-5-fluorouracil derivatives of α- hydroxythiophosphonate were synthesized via oxidation of N′-(2-furanidyl)-N3-(hydroxyalkyl)-5-fluorouracil, followed by addition with O, O-diethyl thiophosphite. The phosphonate products were obtained by oxidation with meta-chloro peroxybenzoic acid(MCPBA) from corresponding thiophosphonates.
