CAJ | 학술논문

AIM: With successful surgical treatment of gastroesophagealreflux disease (GERD), there is interest in understandingthe anti-reflux barrier and its mechanisms of failure. To date,the potential use of vector volumes to predict the DeMeesterscore has not been adequately explored.METHODS: 627 patients in the referral database receivedesophageal manometry and ambulatory 24-hour pHmonitoring. Study data included LES resting pressure (LESP),overall LES length (OL) and abdominal length (AL), totalvector volume (TW) and intrabdominal vector volume (IVV).RESULTS: In cases where LESP, TVV or IVV were all belownormal, there was an 81.4 % probability of a positiveDeMeester score. In cases where all three were normal,there was an 86.9 % probability that the DeMeester scorewould be negative. Receiver-operating characteristics (ROC)for LESP, TW and IW were nearly identical and indicatedno useful cut-off values. Logistic regression demonstratedthat LESP and IVV had the strongest association with apositive DeMeester score; however, the regression formulawas only 76.L % accurate.CONCLUSION: While the indices based on TVV, IW andLESP are more sensitive and specific, respectively, than anysingle measurement, the measurement of vector volumesdoes not add significantly to the diagnosis of GERD.