CAJ | 학술논문

目的：探讨 p53基因异常表达在人癌发生过程的病理生物学作用和临床病理学意义。方法：对人体 1364例不同类型恶性肿瘤 (其中 615例鳞癌， 382例腺癌及 367例其它恶性肿瘤 )及相应良性病变组织进行 p53蛋白表达的免疫组化（ LASB法）检测。结果：恶性肿瘤组织 p53蛋白表达的阳性检出率 56.7％ (773/1364)明显高于良性病变组织 6.7％ (42/628)(P< 0.001)。结论： p53基因的异常表达（基因突变或 /及蛋白积累）是人体多种恶性肿瘤病的普遍现象，可能是人癌发生发展过程中关键的变化之一。免疫组化检测 p53蛋白过度表达可以作为区别良恶性病变有参考价值的指标之一。
목적：탐토 p53기인이상표체재인암발생과정적병리생물학작용화림상병이학의의。방법：대인체 1364례불동류형악성종류 (기중 615례린암， 382례선암급 367례기타악성종류 )급상응량성병변조직진행 p53단백표체적면역조화（ LASB법）검측。결과：악성종류조직 p53단백표체적양성검출솔 56.7％ (773/1364)명현고우량성병변조직 6.7％ (42/628)(P< 0.001)。결론： p53기인적이상표체（기인돌변혹 /급단백적루）시인체다충악성종류병적보편현상，가능시인암발생발전과정중관건적변화지일。면역조화검측 p53단백과도표체가이작위구별량악성병변유삼고개치적지표지일。
Objective：The aim of this study was to investigate the effect of p53 gene alterated expression on human carcinogenesis. Methods： p53 protein expression in 1 364 patients with malignant tumors and 628 benign lesions was detected by immunohistochemistry (LSAB). Results： The frenquency of p53 protein positive was significant higher in malignant tumors [56.67％ (733/1364)] than those in related benign lesions [6.7％ (42/623) (P< 0.001)]; It was revealed the similar situation as compared squamous cell cancer (615), adenocarcinoma (382), and other types of malignancies (367) with their related benign lesions respectively (P< 0.001). Conclusion： Alterated expression of p53 protein (gene multation or protein accumulation) may involve one of the critical events of human carcinogenesis. Detection of p53 overexpression may be a useful biomarkers for assessment of maligant tumors.