CAJ | 학술논문

为探讨北京地区志贺菌耐药趋势,对1994-2001年327株志贺菌对30种抗生素做药敏实验.结果8年来耐氟喹诺酮类菌株逐渐增多,1997-1998耐诺氟沙星菌株达11.6%;耐环丙沙星菌株达16.3%,均比1994显著增加(P＜0.001).从1994-1998志贺菌对氟喹诺酮类中敏菌株也渐增加,且 1999-2001增加迅速.是否预示今后几年氟喹诺酮类耐药株会?速增加,应引起注意.氟喹诺酮类存在部分交叉耐药,耐5种氟喹诺酮类药物的菌株从1995逐渐上升,1999-2001耐药率达8.5%.8年来志贺菌对一代头抱、氨基糖甙类耐药相对稳定,仍可首选治疗急性菌痢.但丁胺卡那和几乎所有头孢类中敏菌株急剧增加.应引起重视.
위탐토북경지구지하균내약추세,대1994-2001년327주지하균대30충항생소주약민실험.결과8년래내불규낙동류균주축점증다,1997-1998내낙불사성균주체11.6%;내배병사성균주체16.3%,균비1994현저증가(P＜0.001).종1994-1998지하균대불규낙동류중민균주야점증가,차 1999-2001증가신속.시부예시금후궤년불규낙동류내약주회?속증가,응인기주의.불규낙동류존재부분교차내약,내5충불규낙동류약물적균주종1995축점상승,1999-2001내약솔체8.5%.8년래지하균대일대두포、안기당대류내약상대은정,잉가수선치료급성균리.단정알잡나화궤호소유두포류중민균주급극증가.응인기중시.
To investigate the trends antibiobic resistance in strains of shigella isolated in Beijing,the susceptibility of30 antimicrobial agents wes observed in 327 Shigella strans isolated from to 2001. The resiance rates of fluoroquinoloes increased gradually over the eight years, and the resistance rates of norfloxacin and ciprofloxacin (11.6% and 16.3% respec tiveiy) during 1997-1998 were significantly higher than that in 1994 (P＜0.001). Meanwhile intemedtrely susceptible stiains of fluoroquinolones also incrased gradually from 1994 to 1998, and increased rapidly during 1999-2001, which sug gests that the resistance rate of fluoroquinolones may increase in the coming years. In addition there wes partial cross resistance among fluoroquinolones, and the rate of resistance to 5 species of fluoroquinolones had been increasing from 2001 anl.It increased to 8.5% during 1999-2001. The resistance rates of Aminoglycoside and the first-generation cephalosporins remained relatively stable over the eight years, can be usesd as the first-line agents for the treatment of dysentery, but in termediately susceptible strains of amikacin and almost all of cephalosporins have increased,which should be noticed.