CAJ | 학술논문

目的:探讨老年人高血压Ouabain抵抗现象机制及钙拮抗剂非洛地平的疗效.方法:47例高血压病(Essential Hypertension,EH)病人,分为老年EH组和非老年EH 组,选择200名健康老年人作对照组.采用放射免疫分析法测定血浆内源性类洋地黄物质(En dogenous digitalis-like compound,EDLC)浓度、EDLC与红细胞结合率(RBC-D%);测定加哇巴因(Ouabain)后红细胞内[Na+]i变化,计算出Ouabain敏感Na+外流速度常数(th e rate content of ouabain sensitive sodium efflux,oKos/h,反映总的Na+泵活性);红细胞内[Na+]i用火焰光度法测定.老年EH组和非老年EH组服非洛地平治疗 3周后复查.结果:老年EH组和非老年EH组RBC-D%、oKos下降,EDLC升高,但老年E H组RBC-D%明显低于非老年EH组,血浆EDLC和oKos高于非老年EH组,Na+泵呈现Ouabain抵抗现象.非洛地平降压治疗后,老年EH病人Na+泵活性升高,EDLC下降;非老年EH者仅Na+泵活性升高,EDLC有升高趋势,两组[Na+]i治疗前后无显著变化 .结论:老年EH病人EDLC与细胞膜亲合力下降,Na+泵呈现Ouabain抵抗现象.钙拮抗剂非洛地平降压治疗可部分改善这种异常.
목적:탐토노년인고혈압Ouabain저항현상궤제급개길항제비락지평적료효.방법:47례고혈압병(Essential Hypertension,EH)병인,분위노년EH조화비노년EH 조,선택200명건강노년인작대조조.채용방사면역분석법측정혈장내원성류양지황물질(En dogenous digitalis-like compound,EDLC)농도、EDLC여홍세포결합솔(RBC-D%);측정가왜파인(Ouabain)후홍세포내[Na+]i변화,계산출Ouabain민감Na+외류속도상수(th e rate content of ouabain sensitive sodium efflux,oKos/h,반영총적Na+빙활성);홍세포내[Na+]i용화염광도법측정.노년EH조화비노년EH조복비락지평치료 3주후복사.결과:노년EH조화비노년EH조RBC-D%、oKos하강,EDLC승고,단노년E H조RBC-D%명현저우비노년EH조,혈장EDLC화oKos고우비노년EH조,Na+빙정현Ouabain저항현상.비락지평강압치료후,노년EH병인Na+빙활성승고,EDLC하강;비노년EH자부Na+빙활성승고,EDLC유승고추세,량조[Na+]i치료전후무현저변화 .결론:노년EH병인EDLC여세포막친합력하강,Na+빙정현Ouabain저항현상.개길항제비락지평강압치료가부분개선저충이상.