CAJ | 학술논문

MicroRNA(miRNA)是一类含21～25个核苷酸长度的单链小分子RNA,其在细胞生长和发育过程的调节中起到了多重作用,miRNA的突变或异位表达与多种肿瘤相关.电离辐射可以诱导miRNA的改变,从而产生致癌或抑癌效果,而且辐射诱导的miRNA表达变化还显示出细胞特异性和性别特异性.
MicroRNA(miRNA)시일류함21～25개핵감산장도적단련소분자RNA,기재세포생장화발육과정적조절중기도료다중작용,miRNA적돌변혹이위표체여다충종류상관.전리복사가이유도miRNA적개변,종이산생치암혹억암효과,이차복사유도적miRNA표체변화환현시출세포특이성화성별특이성.
MicroRNA ( miRNA ) are noncoding RNA of 21～25 nucleotides that act as post-transcriptional regulators of gene expression, it plays a multiple role in the regulation of cell growth and development. miRNA mutation or ectopia expression is associated with a variety of tumor. Ionizing radiation which has a carcinogenic or tumor suppressive effect induces changes in miRNA, miRNA expression changes induced by radiation are also cell-specific and gender-specific.