国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2008年
8期
600-603
,共4页
粒细胞集落刺激因子%脑缺血%造血干细胞%骨髓基质细胞
粒細胞集落刺激因子%腦缺血%造血榦細胞%骨髓基質細胞
립세포집락자격인자%뇌결혈%조혈간세포%골수기질세포
granulocyte colony stimulating factor%cerebral ischemia%hemopoietic stem cell%marrow stromal cell
粒细胞集落刺激因子(G-CSF)可将造血干细胞(HSC)从骨髓中动员到外周血循环中,刺激HSC和骨髓基质细胞(MSC)向脑缺血病灶归巢,促使HSC和MSC与缺血半暗带细胞相互作用,促进神经营养因子产生.G-CSF还具有抗神经元凋亡作用,驱动神经发生.利用G-CSF动员自体HSC和MSC治疗局灶性缺血性脑损伤,可缩小脑梗死体积,促进神经功能恢复.
粒細胞集落刺激因子(G-CSF)可將造血榦細胞(HSC)從骨髓中動員到外週血循環中,刺激HSC和骨髓基質細胞(MSC)嚮腦缺血病竈歸巢,促使HSC和MSC與缺血半暗帶細胞相互作用,促進神經營養因子產生.G-CSF還具有抗神經元凋亡作用,驅動神經髮生.利用G-CSF動員自體HSC和MSC治療跼竈性缺血性腦損傷,可縮小腦梗死體積,促進神經功能恢複.
립세포집락자격인자(G-CSF)가장조혈간세포(HSC)종골수중동원도외주혈순배중,자격HSC화골수기질세포(MSC)향뇌결혈병조귀소,촉사HSC화MSC여결혈반암대세포상호작용,촉진신경영양인자산생.G-CSF환구유항신경원조망작용,구동신경발생.이용G-CSF동원자체HSC화MSC치료국조성결혈성뇌손상,가축소뇌경사체적,촉진신경공능회복.
Granulocyte colony stimulating factor(G-CSF)can mobilize hemopoietic stem cells(HSCs)from bone marrow to peripheral circulation,stimulating HSCs and marrow stromal cells(MSCs)homing to the lesion of cerebral ischemia,contributing to the interactions of HSCs and MSCs with the cells in ischemic penumbra,and promoting the generation of neurotrophic factors.G-CSF also has antiapoptotic effect on neurons and drives neurogenesis.Mobilizing autologous HSCs and MSCs using G-CSF for the treatment of local cerebral ischemic injury may reduce the volume of cerebral infarction,and improve neurological functional recovery.
