CAJ | 학술논문

目的探讨急性高容量血液稀释(AHHD)对全麻患者维库溴铵肌松起效和恢复的影响.方法择期全麻下普通外科手术患者32例,ASA Ⅰ或Ⅱ级,随机分为2组(n=16):对照组和AHHD组.AHHD组AHHD完成并稳定10min后、对照组气管插管完成后,静脉注射维库溴铵负荷剂量0.1 mg/kg.静脉输注维库溴铵维持Tl/Tc 5%～15%.于AHHD前、后各时点测定血生化指标,记录维库溴铵起效时间和恢复时间.结果与对照组比较,AHHD组AHHD后Hct、Hb、血浆总蛋白及白蛋白浓度降低,维库溴铵起效时间和恢复时间均缩短(P＜0.05),肝、肾和凝血功能指标差异无统计学意义(P＞0.05).结论急性高容量血液稀释可缩短全麻患者维库溴铵的肌松起效时间,加快肌松恢复.
목적 탐토급성고용량혈액희석(AHHD)대전마환자유고추안기송기효화회복적영향.방법 택기전마하보통외과수술환자32례,ASA Ⅰ혹Ⅱ급,수궤분위2조(n=16):대조조화AHHD조.AHHD조AHHD완성병은정10min후、대조조기관삽관완성후,정맥주사유고추안부하제량0.1 mg/kg.정맥수주유고추안유지Tl/Tc 5%～15%.우AHHD전、후각시점측정혈생화지표,기록유고추안기효시간화회복시간.결과 여대조조비교,AHHD조AHHD후Hct、Hb、혈장총단백급백단백농도강저,유고추안기효시간화회복시간균축단(P＜0.05),간、신화응혈공능지표차이무통계학의의(P＞0.05).결론 급성고용량혈액희석가축단전마환자유고추안적기송기효시간,가쾌기송회복.
Objective To investigate the effect of acute hypervolemic hemodilution(AHHD)on the onset and recovery of muscle relaxation induced by vecuronium.Methods Thirty-two ASA Ⅰ orⅡpatients undergoing elective surgery under general anesthesia were randomly divided into 2 groups(n=16 each):control group and AHHD group.A loading dose of vecuronium 0.1 mg/kg Was given at 10 min after AHHD following tracheal intubatiom The muscular relaxation was maintained at Tl/Tc 5% to 15% by supplement with intravenous vecuroninm.Blood samples were taken at various times during AHHD for chemical analysis.The onset and recovery time of muscular relaxation were recorded.Results Compared with control group ,Hct,Hb and the concentration of TP and Alb were decreased,and the onset and recovery time of vecuronium were shortened in group AHHD(P＜0.05).Conclusion Acute hypervolemic hemodihtion can shorten the onset and recovery of muscle relaxation of vecuronium in patients under general anethesia.