CAJ | 학술논문

目的观察盐酸戊乙奎醚预先给药对下肢手术患者松止血带后血清白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)浓度的影响.方法择期行单侧下肢手术且术中应用止血带患者30例,ASA分级Ⅰ～Ⅱ级,将患者按随机数字表法分为对照组和研究组,每组15例.麻醉前30 min,研究组静脉滴注盐酸戊乙奎醚0.01～0.02 mg/kg,对照组静脉滴注相应体积的0.9％氯化钠.于止血带充气前即刻(T0)、松止血带前即刻(T1)、松止血带后30 min (T2)、松止血带后60 min(T3)抽取非患侧肢体外周静脉血,采用酶联免疫吸附法测定血清IL-6和NF-α的浓度.结果两组松止血带后相同时间点血清 TNF-α变化量比较差异无统计学意义(P＞0.05)；研究组松止血带后各时间点血清IL-6浓度均较T0下降,对照组均较T0上升,研究组与对照组T3与T0的血清IL-6浓度差比较差异有统计学意义[(-8.8±5.6)ng/L比(10.2±6.7) ng/L,P＜ 0.05].结论盐酸戊乙奎醚预先给药能够降低下肢手术患者松止血带后血清IL-6浓度.
목적 관찰염산무을규미예선급약대하지수술환자송지혈대후혈청백세포개소-6(IL-6)화종류배사인자-α(TNF-α)농도적영향.방법 택기행단측하지수술차술중응용지혈대환자30례,ASA분급Ⅰ～Ⅱ급,장환자안수궤수자표법분위대조조화연구조,매조15례.마취전30 min,연구조정맥적주염산무을규미0.01～0.02 mg/kg,대조조정맥적주상응체적적0.9％록화납.우지혈대충기전즉각(T0)、송지혈대전즉각(T1)、송지혈대후30 min (T2)、송지혈대후60 min(T3)추취비환측지체외주정맥혈,채용매련면역흡부법측정혈청IL-6화NF-α적농도.결과 량조송지혈대후상동시간점혈청 TNF-α변화량비교차이무통계학의의(P＞0.05)；연구조송지혈대후각시간점혈청IL-6농도균교T0하강,대조조균교T0상승,연구조여대조조T3여T0적혈청IL-6농도차비교차이유통계학의의[(-8.8±5.6)ng/L비(10.2±6.7) ng/L,P＜ 0.05].결론 염산무을규미예선급약능구강저하지수술환자송지혈대후혈청IL-6농도.
Objective To observe the effect of penehyclidine hydrochloride (PHC) on serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α ) concentrations following tourniquet deflation in patients undergoing lower limb surgery.Methods Thirty adult patients,scheduled for unilateral lower limb surgery,ASA classification [ - Ⅱ grades,were divided into control group and research group by random number table,each group of 15 cases.Before anesthesia 30 min,PHC in intravenous infusion of 0.01-0.02 mg/kg in research group,the corresponding volume in intravenous infusion of 0.9% sodium chloride in control group.Peripheral venous blood samples were collected immediately before tourniquet inflation (T0,baseline),immediately before tourniquet deflation (T1),30 min (T2) and 60 min (T3) after tourniquet deflation.Serum IL-6 and TNF- α concentrations were measured by enzyme linked immunosorbent assay.Resalts Serum TNF- α change at the same time point after tourniquet deflation was not statistically significant between two groups (P ＞ 0.05).Serum IL-6 concentration was decreased at each time point after tourniquet deflation compared with T0 in research group,while increased in control group.Serum IL-6concentration difference of T3 and T0 had statistically significant between research group and control group [ (-8.8 ± 5.6) ng/L vs.( 10.2 ± 6.7) ng/L,P＜ 0.05].Conclusions PHC in advance can decrease serum IL-6 concentration after tourniquet deflation in patients undergoing lower limb surgery.