中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
24期
1-3
,共3页
宫颈肿瘤%免疫组织化学%ARHI蛋白
宮頸腫瘤%免疫組織化學%ARHI蛋白
궁경종류%면역조직화학%ARHI단백
Uterine cervical neoplasms%Immunohistochemistry%ARHI protein
目的 检测ARHI蛋白在宫颈腺癌组织及正常宫颈腺体组织中的表达情况，探讨其在宫颈腺癌发病机制中的作用。方法 采用免疫组织化学法检测ARHI蛋白在30例宫颈腺癌组织和30例正常宫颈腺体组织中的表达情况，分析ARHI蛋白的表达与宫颈腺癌发生的关系。结果 宫颈腺癌组织中ARHI蛋白阳性表达率[46.67％(14/30)]低于正常宫颈腺体组织[90.00％(27/30)](P＜ 0.05)。ARHI蛋白与宫颈腺癌组织学分级、FIGO分期密切相关(P＜0.05)，与淋巴结转移无相关性(P＞0.05)。结论 ARHI蛋白在宫颈腺癌组织中表达降低，证明ARHI抑癌基因在宫颈腺癌组织中的表达降低可能与宫颈腺癌的发生有关，ARHI蛋白可作为宫颈腺癌病因学的一个新指标。
目的 檢測ARHI蛋白在宮頸腺癌組織及正常宮頸腺體組織中的錶達情況，探討其在宮頸腺癌髮病機製中的作用。方法 採用免疫組織化學法檢測ARHI蛋白在30例宮頸腺癌組織和30例正常宮頸腺體組織中的錶達情況，分析ARHI蛋白的錶達與宮頸腺癌髮生的關繫。結果 宮頸腺癌組織中ARHI蛋白暘性錶達率[46.67％(14/30)]低于正常宮頸腺體組織[90.00％(27/30)](P＜ 0.05)。ARHI蛋白與宮頸腺癌組織學分級、FIGO分期密切相關(P＜0.05)，與淋巴結轉移無相關性(P＞0.05)。結論 ARHI蛋白在宮頸腺癌組織中錶達降低，證明ARHI抑癌基因在宮頸腺癌組織中的錶達降低可能與宮頸腺癌的髮生有關，ARHI蛋白可作為宮頸腺癌病因學的一箇新指標。
목적 검측ARHI단백재궁경선암조직급정상궁경선체조직중적표체정황，탐토기재궁경선암발병궤제중적작용。방법 채용면역조직화학법검측ARHI단백재30례궁경선암조직화30례정상궁경선체조직중적표체정황，분석ARHI단백적표체여궁경선암발생적관계。결과 궁경선암조직중ARHI단백양성표체솔[46.67％(14/30)]저우정상궁경선체조직[90.00％(27/30)](P＜ 0.05)。ARHI단백여궁경선암조직학분급、FIGO분기밀절상관(P＜0.05)，여림파결전이무상관성(P＞0.05)。결론 ARHI단백재궁경선암조직중표체강저，증명ARHI억암기인재궁경선암조직중적표체강저가능여궁경선암적발생유관，ARHI단백가작위궁경선암병인학적일개신지표。
Objective To detect the expression of ARHI protein in adenocarcinoma of the uterine cervix and normal uterine cervix tissue, and explore the pathogenesis of cervical cancer. Methods The expression of ARHI protein in 30 cases of adenocarcinoma of the uterine cervix tissue and 30 cases of normal uterine cervix tissue was detected by immunohistochemistry and analyzed the relationship between ARHI protein and adenocarcinoma of the uterine cervix. Results The expression of ARHI protein in adenocarcinoma of the uterine cervix tissue[46.67％(14/30)]was lower than that in normal uterine cervix tissue[90.00％(27/30)],the difference was significant (P＜0.05). There was intimate correlation between ARHI protein and histological grade, FIGO stage of adenocarcinoma of the uterine cervix tissue (P ＜ 0.05), there was no correlation between ARHI protein and lymphatic metastasis (P＞0.05). Conclusions The expression of ARHI protein in adenooarcinoma of the uterine cervix decreases which indicates the expression of ARHI protein take part in the carcinogenesis of adenocarcinoma of the uterine cervix. It can be used as a new diagnostic indicator of adenocarcinoma of the uterine cervix.
