中华全科医师杂志
中華全科醫師雜誌
중화전과의사잡지
CHINESE JOURNAL OF GENERAL PRACTITIONERS
2010年
5期
320-323
,共4页
纵隔肿瘤%淋巴瘤,大细胞%诊断%Kaplan-Meiers 评估
縱隔腫瘤%淋巴瘤,大細胞%診斷%Kaplan-Meiers 評估
종격종류%림파류,대세포%진단%Kaplan-Meiers 평고
Mediastinal neolasms%Lymphoma,large-cell%Diagnosis%Kaplan-Meiers estimate
目的 探讨纵隔大B细胞淋巴瘤的临床表现、诊断治疗方法以及手术治疗的作用.方法 回顾分析北京协和医院1998年至2008年间19例资料完整的纵隔大B细胞淋巴瘤患者的临床资料,根据手术与否,分为手术组(10例)和非手术组(9例),使用Kaplan-Meier法生存分析,评估患者的生存期、生存率.结果 19例患者的总体平均生存期为44个月,3年生存率为54%;手术组与非手术组的平均生存期分别为44和42个月,3年生存率分别为55%和54%,两者差异均无统计学意义.手术组中5例术前有上腔静脉综合征,术后症状均得到缓解.非手术组9例患者中,3例有上腔静脉综合征,在1～3个周期化学治疗后逐渐缓解.结论 纵隔大B细胞淋巴瘤的手术切除率低,手术对生存期没有显著影响,但是可以在短期内缓解上腔静脉综合征症状,并且能够提供明确的病理诊断.
目的 探討縱隔大B細胞淋巴瘤的臨床錶現、診斷治療方法以及手術治療的作用.方法 迴顧分析北京協和醫院1998年至2008年間19例資料完整的縱隔大B細胞淋巴瘤患者的臨床資料,根據手術與否,分為手術組(10例)和非手術組(9例),使用Kaplan-Meier法生存分析,評估患者的生存期、生存率.結果 19例患者的總體平均生存期為44箇月,3年生存率為54%;手術組與非手術組的平均生存期分彆為44和42箇月,3年生存率分彆為55%和54%,兩者差異均無統計學意義.手術組中5例術前有上腔靜脈綜閤徵,術後癥狀均得到緩解.非手術組9例患者中,3例有上腔靜脈綜閤徵,在1～3箇週期化學治療後逐漸緩解.結論 縱隔大B細胞淋巴瘤的手術切除率低,手術對生存期沒有顯著影響,但是可以在短期內緩解上腔靜脈綜閤徵癥狀,併且能夠提供明確的病理診斷.
목적 탐토종격대B세포림파류적림상표현、진단치료방법이급수술치료적작용.방법 회고분석북경협화의원1998년지2008년간19례자료완정적종격대B세포림파류환자적림상자료,근거수술여부,분위수술조(10례)화비수술조(9례),사용Kaplan-Meier법생존분석,평고환자적생존기、생존솔.결과 19례환자적총체평균생존기위44개월,3년생존솔위54%;수술조여비수술조적평균생존기분별위44화42개월,3년생존솔분별위55%화54%,량자차이균무통계학의의.수술조중5례술전유상강정맥종합정,술후증상균득도완해.비수술조9례환자중,3례유상강정맥종합정,재1～3개주기화학치료후축점완해.결론 종격대B세포림파류적수술절제솔저,수술대생존기몰유현저영향,단시가이재단기내완해상강정맥종합정증상,병차능구제공명학적병리진단.
Objective To study clinical manifestations, diagnosis, treatment, as well as effect of surgical operation, of primary mediastinal large B-cell lymphoma (PMBCL).Methods Data of 19 patients of PMBCL with complete clinical and pathological records hospitalized at Peking Union Medical College Hospital during 1998 to 2008 were retrospectively reviewed and analyzed.Kaplan-Meier method was used to estimate their survival time and survival rate in comparison of efficacy in those with surgical operation to those without it.Results Overall three-year survival rate was 54% for all the 19 patients, 55% for those with surgical operation and 54% without it, respectively, with an average survival time of 44 months, 44 months for those with surgical operation and 42 months without it, respectively, but not reaching at statistical significance.Symptoms of superior vena cava syndrome in five cases at admission relieved immediately after surgical operation, but symptoms of superior vena cava syndrome in three of nine cases in non-surgical group relieved gradually one to three weeks after chemotherapy.Conclusions Surgical operation has no significant effect on survival in patients with PMBCL, but it can relieve syndrome of superior vena cava syndrome and provide accurate pathological diagnosis.
