CAJ | 학술논문

目的制备米诺地尔醇脂质体并评价其质量.方法采用乙醇注入法制备米诺地尔醇脂质体,以包封率为评价指标进行正交试验筛选出最佳的处方和工艺.采用HPLC测定主药含量、透析袋法测定醇脂质体的包封率.并对其粒径、电位、包封率等理化性质进行研究.结果各因素最佳的水平组合:药脂重量比为1:10、胆固醇与大豆磷脂的重量比为1:2、无水乙醇为处方量的30%.所制醇脂质体为乳黄色,平均粒径为1.103 μm,Zeta电位为-3.69 mV,平均包封率为66.7%.结论米诺地尔醇脂质体的制备工艺简便可行,质量稳定可控,为开发新剂型奠定了实验基础.
목적 제비미낙지이순지질체병평개기질량.방법 채용을순주입법제비미낙지이순지질체,이포봉솔위평개지표진행정교시험사선출최가적처방화공예.채용HPLC측정주약함량、투석대법측정순지질체적포봉솔.병대기립경、전위、포봉솔등이화성질진행연구.결과 각인소최가적수평조합:약지중량비위1:10、담고순여대두린지적중량비위1:2、무수을순위처방량적30%.소제순지질체위유황색,평균립경위1.103 μm,Zeta전위위-3.69 mV,평균포봉솔위66.7%.결론 미낙지이순지질체적제비공예간편가행,질량은정가공,위개발신제형전정료실험기출.
Objective To prepare minoxidil liposomes alcohol and study its quality.Methods The liposomes alcohol was prepared by ethanol injection method,then by the efficiency of encapsulating of liposomes alcohol of minoxidil,using orthogonal design method to screen out an optimal formula and technology.The content of minoxidil was determined by HPLC,the entrapment efficiency was determined by dialysis method.The mean particle size,zeta potential,entrapment efficiency(EE%),and physical or chemical properties of the minoxidil were studied.Results The optimal formula and technique were as follows: ratio of drug and Soybean phosphatide was 1∶10,ratio of cholesterol and soybean phosphatide was 1∶2,and the anhydrous ethanol of formula was 30%.The liposomes alcohol system was milk yellow,smooth particles with average size of 1.103 μm,zeta potential -3.69 mV and entrapment efficiency 66.7%.Conclusion The preparation technique is simple and convenient with stable and controllable quality.The liposomes alcohol can be used as new sustained release preparation for minoxidil.