国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
12期
1780-1782
,共3页
甲氨蝶呤%慢性湿疹%疗效%安全性
甲氨蝶呤%慢性濕疹%療效%安全性
갑안접령%만성습진%료효%안전성
Methotrexate%Chronic eczema%Efficacy%Safety
目的 观察小剂量免疫抑制剂甲氨蝶呤对慢性复发性湿疹患者的治疗效果及安全性.方法 选择2009至2010年在我院皮肤科门诊就诊的成人慢性湿疹患者40例,入选患者均经过长时间的抗组胺及外用激素类软膏效果不佳,反复发作.每周给予甲氨蝶呤10mg一次顿服,第2日起给予叶酸5mg,tid口服;皮损局部处理依据皮疹性质对症处理.采用EASI评分表进行疗效评价;治疗前后及治疗过程定期行胸片、血尿常规、肝功能检测,评估其治疗的安全性.结果 治疗第6周和第8周总有效率分别达到76.31％和81.58％;半年复发率为15.62％.在治疗过程中,只有少数患者出现胃肠道反应、头痛、月经延长等轻微不良反应,未见肝肾功能损害、肺纤维化、造血功能抑制等严重不良反应.结论 口服甲氨蝶呤对一般抗组胺药物及外用激素软膏治疗无效的成人患者具有良好的疗效,毒副反应小,治疗安全性高,值得临床推广.
目的 觀察小劑量免疫抑製劑甲氨蝶呤對慢性複髮性濕疹患者的治療效果及安全性.方法 選擇2009至2010年在我院皮膚科門診就診的成人慢性濕疹患者40例,入選患者均經過長時間的抗組胺及外用激素類軟膏效果不佳,反複髮作.每週給予甲氨蝶呤10mg一次頓服,第2日起給予葉痠5mg,tid口服;皮損跼部處理依據皮疹性質對癥處理.採用EASI評分錶進行療效評價;治療前後及治療過程定期行胸片、血尿常規、肝功能檢測,評估其治療的安全性.結果 治療第6週和第8週總有效率分彆達到76.31％和81.58％;半年複髮率為15.62％.在治療過程中,隻有少數患者齣現胃腸道反應、頭痛、月經延長等輕微不良反應,未見肝腎功能損害、肺纖維化、造血功能抑製等嚴重不良反應.結論 口服甲氨蝶呤對一般抗組胺藥物及外用激素軟膏治療無效的成人患者具有良好的療效,毒副反應小,治療安全性高,值得臨床推廣.
목적 관찰소제량면역억제제갑안접령대만성복발성습진환자적치료효과급안전성.방법 선택2009지2010년재아원피부과문진취진적성인만성습진환자40례,입선환자균경과장시간적항조알급외용격소류연고효과불가,반복발작.매주급여갑안접령10mg일차돈복,제2일기급여협산5mg,tid구복;피손국부처리의거피진성질대증처리.채용EASI평분표진행료효평개;치료전후급치료과정정기행흉편、혈뇨상규、간공능검측,평고기치료적안전성.결과 치료제6주화제8주총유효솔분별체도76.31％화81.58％;반년복발솔위15.62％.재치료과정중,지유소수환자출현위장도반응、두통、월경연장등경미불량반응,미견간신공능손해、폐섬유화、조혈공능억제등엄중불량반응.결론 구복갑안접령대일반항조알약물급외용격소연고치료무효적성인환자구유량호적료효,독부반응소,치료안전성고,치득림상추엄.
Objective To further determine the efficacy and safety,of low dosage methotrexate therapy in adults with chronic eczema.Methods Forty adult patients with chronic eczema treated by methotrexate in our dermatology clinic from 2009 to 2010 had been chosen in the study.All had failed prolonged therapy with oral anti-histamines and local corticosteroid creams.10 mg of methotrexate was given orally once a week along with folic acid supplements 6 days a week.Additional therapies included mollient cream.During the entire treatment blood test,urea,liver and kidney function test and chest X-ray check were regularly conducted and evaluated the safety.Results The evaluation was made on EMSI assessment after 6 and 8 weeks of MTX use,and showed that 76.31％ (29/38) and 31/38( 81.58％ )of patients improved;recurrence rate in half year was 15.62％.There were only slight adverse effects like gastrointestinal tract,headache,menstrual extension,without any severe adverse reactions like hepatorenal function,pulmonary fibrosis and hematopoiesis function during the treatment.Conelusions Taking methotrexate orally is an effective and safe therapeutic alternative method for adults with chronic eczema in patients unresponsive to local and other systemic therapies.No serious adverse effects occur and it' s worthy for clinical application.
