CAJ | 학술논문

目的探讨急性白血病(AL)患者化疗后CD+34细胞数量变化对粒细胞集落刺激因子(G-CSF)的应用和判断是否早期缓解的指导意义.方法 50例初发白血病患者化疗后于WBC最低点应用G-CSF,不同时间测定外周血WBC、中性粒细胞数(MNC)、Plt与CD+34细胞数量,并对它们的相关性进行研究.结果化疗后极期CD+34细胞为(3.05±2.47)个/μl,与化疗前比较明显降低(P＜0.01),在恢复期显著增加,为(113.46±77.16)个/μl(P＜0.01).WBC、MNC、Plt数量变化与CD+34细胞数量呈显著正相关(r分别为0.970、0.837、0.850,P均＜0.01).当极期末WBC/CD+34＞400,能早期判断AL患者是否缓解,CD+34＜5/μl,可应用G-CSF,CD+34＞5/μl,停用G-CSF.结论白血病患者化疗后监测CD+34细胞数量变化,对早期判断是否缓解和G-CSF的应用具有重要的指导意义.
목적 탐토급성백혈병(AL)환자화료후CD+34세포수량변화대립세포집락자격인자(G-CSF)적응용화판단시부조기완해적지도의의.방법 50례초발백혈병환자화료후우WBC최저점응용G-CSF,불동시간측정외주혈WBC、중성립세포수(MNC)、Plt여CD+34세포수량,병대타문적상관성진행연구.결과 화료후겁기CD+34세포위(3.05±2.47)개/μl,여화료전비교명현강저(P＜0.01),재회복기현저증가,위(113.46±77.16)개/μl(P＜0.01).WBC、MNC、Plt수량변화여CD+34세포수량정현저정상관(r분별위0.970、0.837、0.850,P균＜0.01).당겁기말WBC/CD+34＞400,능조기판단AL환자시부완해,CD+34＜5/μl,가응용G-CSF,CD+34＞5/μl,정용G-CSF.결론 백혈병환자화료후감측CD+34세포수량변화,대조기판단시부완해화G-CSF적응용구유중요적지도의의.
Objective To explore the clinical significance of the CD+34 cell variance to the application of G-CSF and early judgement of complete remission(CR)in the acute leukemia patients after chemotherapy.Methods G-CSF was applied in the lowest period of WBC in 50 acute leukemia patients after chemotherapy.WBC,MNC,Pit,CD+34 cell were detected in different time and the correlation was studied between them.Results The count of CD;4 cell decreased significantly in the end of the lowest period (3.05±2.47)/μ1,(P＜0.01)and increased significantly(113.46±77.16)/μl,(P＜0.01)in the recovering period.The count variance of WBC MNC and Plt has significant correlation compare with CD+34 cell(r=0.970,0.837,0.850,P＜0.01)in the lowest period,when WBC/CD+34＞ 400,the patient probably achieved CR,CD+34＜5/μl,G-CSF Can be used safely,however,CD+34＞5/μ1,G-CSF should be stopped.Conclusion To detect the count of CD+34 cell can provide many useful informations which can help us to judge the early CR and use the GCSF correctly.