中华胰腺病杂志
中華胰腺病雜誌
중화이선병잡지
CHINESE JOURNAL OF PANCREATOLOGY
2010年
2期
86-88
,共3页
薛育政%刘宗良%俞宪民%陆宇峰%戴泓%尹群%李建平
薛育政%劉宗良%俞憲民%陸宇峰%戴泓%尹群%李建平
설육정%류종량%유헌민%륙우봉%대홍%윤군%리건평
胰腺炎,急性坏死性%5-羟色胺%脂肪酸结合蛋白质类%肠功能障碍
胰腺炎,急性壞死性%5-羥色胺%脂肪痠結閤蛋白質類%腸功能障礙
이선염,급성배사성%5-간색알%지방산결합단백질류%장공능장애
Pancreatitis,acute necrotizing%5-hydroxytryptamine%Fatty acid-binding proteins%Intestinal dysfunction
目的 检测苇症急性胰腺炎(SAP)伴肠功能障碍患者血5-羟色胺(5-HT)及尿液中肠脂肪酸结合蛋白(iFABP)水平,探讨其临床应用价值.方法 ELASA法检测42例SAP伴肠功能障碍患者入院第1天、第3天及第7天血5-HT及尿iFABP的水平,同时记录肠鸣音次数;以20例健康体检人员作为对照组.结果 健康对照组平均肠鸣音次数为(5.6±2.3)次/min.SAP组入院第1天、第3天及第7天肠鸣音次数分别为(2.3±0.7)次/min、(1.7±0.2)次/min与(3.1±1.1)次/min,均较健康对照组显著减少(P值均<0.01).对照组血5-HT含量为(86.7±9.5)ng/ml,SAP组第1天、第3天、第7天含量分别为(112.0±17.8)ng/ml、(130.5±19.7)ng/ml、(107.9±16.3)ng/ml;对照组尿iFABP含量为(90.5±19.8)pg/ml,SAP组分别为(1250.2±425.3)pg/ml、(1586.9±523.4)pg/ml、(1154.6±394.0)pg/ml.SAP组的血5-HT和尿iFABP含量均较对照组显著增加(P值均<0.01);SAP组第3天的含量又较第1天及第7天显著增高,而第1天与第7天之问无显著差异.结论 在SAP早期检测血5-HT及尿iFABP可有效评估患者的肠功能状况,有潜在的临床应用价值.
目的 檢測葦癥急性胰腺炎(SAP)伴腸功能障礙患者血5-羥色胺(5-HT)及尿液中腸脂肪痠結閤蛋白(iFABP)水平,探討其臨床應用價值.方法 ELASA法檢測42例SAP伴腸功能障礙患者入院第1天、第3天及第7天血5-HT及尿iFABP的水平,同時記錄腸鳴音次數;以20例健康體檢人員作為對照組.結果 健康對照組平均腸鳴音次數為(5.6±2.3)次/min.SAP組入院第1天、第3天及第7天腸鳴音次數分彆為(2.3±0.7)次/min、(1.7±0.2)次/min與(3.1±1.1)次/min,均較健康對照組顯著減少(P值均<0.01).對照組血5-HT含量為(86.7±9.5)ng/ml,SAP組第1天、第3天、第7天含量分彆為(112.0±17.8)ng/ml、(130.5±19.7)ng/ml、(107.9±16.3)ng/ml;對照組尿iFABP含量為(90.5±19.8)pg/ml,SAP組分彆為(1250.2±425.3)pg/ml、(1586.9±523.4)pg/ml、(1154.6±394.0)pg/ml.SAP組的血5-HT和尿iFABP含量均較對照組顯著增加(P值均<0.01);SAP組第3天的含量又較第1天及第7天顯著增高,而第1天與第7天之問無顯著差異.結論 在SAP早期檢測血5-HT及尿iFABP可有效評估患者的腸功能狀況,有潛在的臨床應用價值.
목적 검측위증급성이선염(SAP)반장공능장애환자혈5-간색알(5-HT)급뇨액중장지방산결합단백(iFABP)수평,탐토기림상응용개치.방법 ELASA법검측42례SAP반장공능장애환자입원제1천、제3천급제7천혈5-HT급뇨iFABP적수평,동시기록장명음차수;이20례건강체검인원작위대조조.결과 건강대조조평균장명음차수위(5.6±2.3)차/min.SAP조입원제1천、제3천급제7천장명음차수분별위(2.3±0.7)차/min、(1.7±0.2)차/min여(3.1±1.1)차/min,균교건강대조조현저감소(P치균<0.01).대조조혈5-HT함량위(86.7±9.5)ng/ml,SAP조제1천、제3천、제7천함량분별위(112.0±17.8)ng/ml、(130.5±19.7)ng/ml、(107.9±16.3)ng/ml;대조조뇨iFABP함량위(90.5±19.8)pg/ml,SAP조분별위(1250.2±425.3)pg/ml、(1586.9±523.4)pg/ml、(1154.6±394.0)pg/ml.SAP조적혈5-HT화뇨iFABP함량균교대조조현저증가(P치균<0.01);SAP조제3천적함량우교제1천급제7천현저증고,이제1천여제7천지문무현저차이.결론 재SAP조기검측혈5-HT급뇨iFABP가유효평고환자적장공능상황,유잠재적림상응용개치.
Objective To determine the level and clinical significance of 5-hydroxytryptamine (5-HT) and intestinal fatty acid binding protein (iFABP) in patients of severe acute pancreatitis (SAP) with intestinal dysfunction. Methods The serum and urine in 42 cases of SAP with intestinal dysfunction were collected at day 1, 3 and 7 after admission, respectively. The numbers of bowel sounds were recorded. 20 health subjects were selected as the control. Results The numbers of bowel sounds in health subjects were 5.6 ± 2.3/min. The numbers of bowel sounds in SAP patients at day 1,3 and 7 were 2.3 ± 0.7/min, 1.7 ± 0.2/min and 3.1 ± 1.1/min, respectively;which were significantly lower than that in the control group (P < 0.01). The level of 5-HT in the control group was(86.7 ± 9.5)ng/ml, while the levels of 5-HT in the SAP patients at day 1, 3 and 7 were (112.0 ± 17.8) ng/ml, (130.5 ± 19.7) ng/ml, (107.9 ± 16.3) ng/ml. The level of urine iFABP in the control group was (90.5 ± 19.8) pg/ml, while the levels of urine iFABP in the SAP patients were (1250.2 ± 425.3) pg/ml, (1586.9 ± 523.4) pg/ml, (1154.6 ± 394.0) pg/ml. The levels of 5-HT and urine iFABP in the SAP patients all were significantly higher than those in the control group (P <0.01). The levels of 5-HT and urine iFABP in the SAP patients at day 3 were significantly higher than those in the day 1 and day 7, while there was no significant difference between the two groups. Conclusions Determination of serum 5-HT and urine iFABP in patients with early SAP could effectively evaluate the intestinal function, and it may have potential clinical significance.
